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Updated: May 27, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility
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Published on: May 30, 2025

[Oral paroxetine for premature ejaculation: a randomized controlled study].

Zhi-yong Gong1, Tie-long Tang, Shu Cui

  • 1Department of Urology, The Affiliated Hospital of Chuanbei Medical University, Nanchong, Sichuan 637000, China. gzy009@yahoo.com.cn

Zhonghua Nan Ke Xue = National Journal of Andrology
|November 5, 2011
PubMed
Summary
This summary is machine-generated.

Paroxetine significantly improved intravaginal ejaculatory latency time (IELT) and sexual satisfaction in men with premature ejaculation (PE). This 30-day treatment demonstrated clear therapeutic efficacy for PE patients.

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Area of Science:

  • Pharmacology
  • Urology
  • Sexual Medicine

Context:

  • Premature ejaculation (PE) is a common male sexual dysfunction.
  • Existing treatments for PE have varying efficacy and side effect profiles.
  • Selective serotonin reuptake inhibitors (SSRIs) are being investigated for PE treatment.

Purpose:

  • To validate the therapeutic efficacy of paroxetine in treating premature ejaculation (PE).
  • To assess the impact of paroxetine on intravaginal ejaculatory latency time (IELT) and sexual satisfaction in PE patients.

Summary:

  • A randomized controlled trial involving 80 PE patients was conducted over 4 weeks.
  • Patients received either paroxetine (20 mg/day) or a placebo.
  • Post-treatment assessment showed significantly improved IELT and sexual satisfaction in the paroxetine group compared to placebo.

Impact:

  • Paroxetine at 20 mg/day for 30 days effectively improves IELT and sexual satisfaction in PE patients.
  • This study supports paroxetine as a potential pharmacological treatment option for premature ejaculation.
  • Findings contribute to understanding SSRI efficacy in managing male sexual dysfunction.