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Effective control of hypertension in adults with chronic kidney disease

L Adhikary1, A Koirala, B Gautam

  • 1Department of Medicine, Kathmandu Medical College Teaching Hospital, Sinamangal, Kathmandu, Nepal. adhikarylaxu@hotmail.com

JNMA; Journal of the Nepal Medical Association
|November 5, 2011
PubMed

Insights

Hypertension control in Chronic Kidney Disease (CKD) patients is challenging. Effective blood pressure management in CKD often requires a combination of three antihypertensive drugs.

Area of Science:

  • Nephrology
  • Cardiology
  • Pharmacology

Background:

  • Hypertension management in Chronic Kidney Disease (CKD) is complex.
  • Achieving adequate blood pressure control in CKD patients presents significant challenges.

Purpose of the Study:

  • To evaluate the effectiveness of different antihypertensive drug classes for controlling hypertension in adults with CKD.
  • To analyze the adequacy of blood pressure control in CKD patients.

Main Methods:

  • A cross-sectional observational study included 85 CKD patients.
  • CKD defined by glomerular filtration rate <60 ml/min/1.73 m² or albuminuria.
  • Adequate blood pressure control defined as SBP ≤130 and DBP ≤80 mm Hg.

Main Results:

  • 51.4% of CKD patients required a three-drug antihypertensive combination for effective control.
  • Only 21% of hypertensive CKD patients achieved control with two drugs.

Conclusions:

  • A combination of three antihypertensive drugs is most effective for adequate blood pressure control in CKD patients.
  • Fewer than three antihypertensive drugs resulted in poor blood pressure control.
Abstract

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