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[Recurrent herpetic encephalitis].

B Brochet1, P Henry, A Piquemal-Baluard

  • 1Service de Neurologie, Hôpital Pellegrin-Tripode, Bordeaux.

Revue Neurologique
|January 1, 1990
PubMed
Summary
This summary is machine-generated.

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Recurrent herpes simplex encephalitis (HSE) can present with neurological deficits. Early antiviral treatment with acyclovir and vidarabine can lead to remission, though cognitive deficits may persist.

Area of Science:

  • Neurology
  • Infectious Diseases
  • Virology

Background:

  • Herpes simplex encephalitis (HSE) is a severe neurological condition.
  • Recurrent HSE is rare but poses diagnostic and therapeutic challenges.

Observation:

  • A 64-year-old woman presented with recurrent episodes of encephalitis.
  • Symptoms included hemiparesis, coma, meningitis, and cognitive deficits.
  • Diagnosis was confirmed by serology, CSF analysis, MRI, and brain biopsy showing herpes simplex virus type 1 (HSV1).

Findings:

  • Intrathecal synthesis of HSV-specific antibodies confirmed HSE.
  • Acyclovir treatment led to motor improvement but slow recovery of neuropsychological deficits.
  • Combined acyclovir and vidarabine therapy resulted in complete remission.

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Implications:

  • This case highlights the possibility of recurrent HSE.
  • Prompt diagnosis and aggressive antiviral therapy are crucial for managing recurrent HSE.
  • Long-term neuropsychological deficits may require continued management.