Early alterations in left ventricular diastolic function in normotensive diabetic patients
Anna Capra1, Maurizio Galderisi, Cristina Giannattasio
1Clinica Medica, San Gerardo Hospital Monza and Milano-Bicocca University, Milano.
Blood Pressure
|November 5, 2011
Summary
Cardiac abnormalities in type 2 diabetes occur very early, even in uncomplicated cases. Pulse tissue Doppler analysis reveals diastolic dysfunction in normotensive diabetics, while hypertensive diabetics show more significant cardiac changes.
Area of Science:
- Cardiology
- Diabetology
- Medical Imaging
Background:
- Diabetes mellitus is associated with cardiac structural and functional alterations.
- The early onset of these cardiac changes in diabetes remains unclear.
Purpose of the Study:
- To investigate cardiac functional abnormalities in recent-onset, uncomplicated diabetic patients.
- To compare cardiac function in normotensive and hypertensive diabetic individuals.
Main Methods:
- Echocardiography and pulse tissue Doppler analysis were used.
- 40 diabetic patients (24 normotensive, 16 hypertensive) were studied.
- Data were compared to healthy controls.
Main Results:
- Left ventricular remodeling was more pronounced in hypertensive diabetics.
- Diastolic dysfunction was detected by pulse tissue Doppler but not conventional methods.
- Normotensive diabetics showed early diastolic dysfunction via tissue Doppler.
Conclusions:
- Cardiac abnormalities are early phenomena in type 2 diabetes.
- Pulse tissue Doppler is crucial for detecting early diastolic dysfunction.
- Hypertension exacerbates cardiac alterations in diabetic patients.
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