[The differentiation of A-insulocytes in the human embryonic pancreas]

In the differentiation of A-insulocytes in the human pancreas the following stages were distinguished: nondifferentiated cells of the epithelial anlage (5-6 weeks)--cell of primary duct (5-6 weeks)--duct cell containing lumps of secretory material (7-8 weeks)--cell precursor of A-insulocyte containing immature secretory granules (7-8 weeks)--A-insulocyte containing separate mature granules (9-10 weeks)--mature A-insulocyte (9-10 weeks). All this is accompanied by appearance at the 7-8 week of glucagon in the pancreatic tissue (76.20 +/- 17.28 ng/mg of wet tissue). The content of glucagon rises in 9-10 weeks 8.3 times.