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TREM-1 expression on neutrophils and monocytes of septic patients: relation to the underlying infection and the

Thekla Poukoulidou1, Aikaterini Spyridaki, Ira Mihailidou

  • 14th Department of Internal Medicine, University of Athens, Medical School, ATTIKON General Hospital, 1 Rimini Str,, 12462 Athens, Greece. tpoukoulidou@hotmail.com

BMC Infectious Diseases
|November 5, 2011
PubMed
Abstract

Insights

The expression of TREM-1 on immune cells decreases as sepsis progresses to severe sepsis/septic shock, depending on the infection type and pathogen. This finding is crucial for understanding sepsis progression.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Limited understanding of ligands triggering TREM-1 expression on neutrophils and monocytes.
  • TREM-1 (Triggering Receptor Expressed on Myeloid cells-1) plays a role in immune responses during infection.

Purpose of the Study:

  • To investigate the role of infection type and causative pathogen in TREM-1 expression during sepsis.
  • To analyze changes in TREM-1 expression from sepsis to severe sepsis/septic shock.

Main Methods:

  • Collected peripheral blood from 125 sepsis and 88 severe sepsis/septic shock patients.
  • Identified causative pathogens in 91 patients across various infection types (pyelonephritis, pneumonia, IAIs, bacteremia).
  • Utilized flow cytometry to quantify TREM-1 expression on isolated monocytes and neutrophils.

Main Results:

  • TREM-1 expression on neutrophils and monocytes was significantly lower in severe sepsis/septic shock compared to sepsis for intra-abdominal infections and VAP/HAP.
  • For Gram-negative infections and polymicrobial infections, monocyte TREM-1 expression decreased significantly from sepsis to severe sepsis/septic shock.

Conclusions:

  • The reduction in TREM-1 expression during sepsis progression is contingent upon the specific infection and the identified pathogen.
  • TREM-1 expression serves as a potential biomarker influenced by infection characteristics in sepsis.

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