Related Experiment Video
Updated: May 27, 2026
Anteromesial Temporal Lobectomy for Medically Intractable Temporal Lobe Epilepsy: An Operative Study
Published on: August 15, 2025
Long term outcomes in patients with preoperative generalized interictal epileptiform abnormalities following
Brian D Moseley1, Shobhit Sinha, Fredric B Meyer
1Department of Neurology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. moseley.brian@mayo.edu
Abstract:
We evaluated long term surgical outcomes in 21 patients with temporal lobe epilepsy and presurgical generalized interictal epileptiform discharges (IEDs). Following amygdalohippocampectomy, 12 patients (57.1%) were noted to have favorable outcomes (Engel classification of I-II). Favorable outcomes were significantly associated with a history of auras prior to seizure onset (p=0.021), the absence of generalized IEDs on postoperative EEG (p=0.024), and the presence of focal slowing on postoperative EEG (p=0.045).
