Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...

Pulmonary Cycle: Exhalation

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...

Pneumothorax-II

Pneumothorax-II

Pneumothorax is a medical condition defined by the buildup of air in the pleural space between the lungs and the chest wall. This accumulation of air can lead to partial or complete lung collapse, resulting in a range of clinical manifestations. Understanding the clinical presentation and effective management strategies is crucial for healthcare professionals in providing timely and appropriate care to individuals with pneumothorax.
Clinical Manifestations:

The Bronchial Tree

The Bronchial Tree

The human bronchi and bronchial tree play a crucial role in the respiratory system, facilitating the exchange of oxygen and carbon dioxide. Let's delve into the intricate structure and functions of these respiratory components.
The trachea, commonly known as the windpipe, is a tube that connects the larynx (voice box) to the bronchi. At a point called the carina, it bifurcates into two primary bronchi. The right primary bronchus is wider, shorter, and more vertical than the left primary...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Vitronectin metabolically programs profibrotic macrophages in 3D cultures and idiopathic pulmonary fibrosis.

Science advances·2026

Same author

Ubiquitin Chloromethylketone Probe Enables Activity-based, Selective Protein Profiling of E2 Ubiquitin Conjugating Enzymes.

bioRxiv : the preprint server for biology·2026

Same author

Multi-omics biomarkers of endothelial dysregulation preceding chronic lung allograft dysfunction: A prospective cohort study.

PLoS medicine·2026

Same author

NAE1/UBA3-UBE2M are E1 and E2 enzymes for the URM1 modification.

Nature communications·2026

Same author

Validity of Alfred Step Test Exercise Protocol (A-STEP) as a Surrogate VO<sub>2Max</sub> Cardiopulmonary Exercise Test (CPET) to Cycle Ergometry in Adults With Cystic Fibrosis.

Canadian respiratory journal·2026

Same author

Multi-center open-label tacrolimus inhalation powder trial evaluating safety, tolerability, efficacy, and pharmacokinetics in adult lung transplant recipients with significant renal impairment.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2026

Search research articles

Related Experiment Video

Updated: May 27, 2026

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation

Published on: November 10, 2023

Proliferating bronchial webs after lung transplantation.

Dominic T Keating¹, Glen P Westall, Alan Pham

¹Lung Transplant Unit, Department of Allergy, Immunology and Respiratory Medicine, Alfred Hospital, Melbourne, Victoria, Australia. d.keating@alfred.org.au

The Annals of Thoracic Surgery

|November 5, 2011

Summary

Bronchial webs caused lung function decline in a lung transplant patient two years post-transplant. These inflammatory webs became resistant to treatment, posing unique clinical challenges.

More Related Videos

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

Related Experiment Videos

Last Updated: May 27, 2026

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation

Published on: November 10, 2023

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

Area of Science:

Pulmonology
Transplant Surgery
Immunology

Background:

Lung transplantation is a life-saving procedure for end-stage lung disease.
Post-transplant complications can significantly impact long-term graft survival and patient outcomes.
Bronchial webs are rare airway anomalies.

Observation:

A lung transplant recipient experienced a progressive decline in lung function two years after surgery.
The decline was associated with the development of bronchial webs with an inflammatory component.
Standard therapies proved ineffective against the evolving bronchial webs.

Findings:

Pathological examination revealed inflammatory bronchial webs.
The webs demonstrated resistance to established treatment modalities.
This case highlights an unusual post-transplant airway complication.

Implications:

Understanding the pathogenesis of inflammatory bronchial webs is crucial for managing lung transplant recipients.
Novel therapeutic strategies may be required for treatment-resistant bronchial webs.
This case contributes to the literature on rare lung transplant complications and airway pathology.