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AVPR2 gene and weight changes during triathlons.

L de Milander¹, M A Kun, A V September

¹Human Biology, University of Cape Town, South Africa.

International Journal of Sports Medicine

|November 5, 2011

Summary

Genetic variations in the arginine vasopressin receptor 2 (AVPR2) gene were linked to greater body weight (BW) loss in Ironman triathletes. These findings suggest a genetic influence on BW changes during endurance events via the vasopressin system.

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Area of Science:

Endocrinology
Human Physiology
Genetics

Background:

The arginine vasopressin receptor 2 (AVPR2) is crucial for water balance and osmotic regulation.
Understanding genetic factors influencing physiological responses during extreme endurance events is important.

Purpose of the Study:

To investigate associations between single nucleotide polymorphisms (SNPs) in the AVPR2 gene and changes in serum sodium and body weight (BW) in Ironman triathletes.
To explore the potential genetic contribution to BW loss during endurance exercise.

Main Methods:

Genotyping of 570 Caucasian male Ironman triathletes for AVPR2 SNPs.
Measurement of pre- and post-race serum sodium and BW.
Categorization of triathletes based on relative BW loss (0-3%, 3-5%, >5%).

Main Results:

A significant linear trend was observed for the distribution of minor AVPR2 haplotypes (GCT, GTC, GCC) across BW loss groups (p=0.010).
The group experiencing >5% BW loss exhibited the highest prevalence of minor haplotypes (4.7%).

Conclusions:

Minor haplotype constructs of AVPR2 SNPs are associated with increased BW loss during Ironman Triathlons.
This suggests a potential genetic role of the arginine vasopressin system in modulating BW changes during prolonged endurance exercise.