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05:31
Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
Serum MMP-9 is elevated in children with asthma
1Department of Clinical Laboratory, Affiliated Hospital of Hainan Medical College, Haikou, Hainan 571101, PR China. zhu_hong1970@126.com
Molecular Medicine Reports
|November 5, 2011
Summary
Elevated matrix metalloproteinase-9 (MMP-9) serum levels are linked to childhood asthma, but the MMP-9 -1562C/T gene polymorphism shows no association with the disease
Area of Science:
- Biochemistry
- Genetics
- Pediatrics
Background:
- Matrix metalloproteinase-9 (MMP-9) is implicated in inflammatory processes.
- Understanding MMP-9's role in childhood asthma is crucial for potential therapeutic targets.
Purpose of the Study:
- To investigate the association between serum MMP-9 concentrations and the MMP-9 -1562C/T gene polymorphism in children with asthma.
- To determine if MMP-9 levels or its genetic variations correlate with the pathogenesis of childhood asthma.
Main Methods:
- Serum MMP-9 levels were quantified using enzyme-linked immunosorbent assay (ELISA).
- MMP-9 -1562C/T gene polymorphism was analyzed via polymerase chain reaction and restriction fragment-length polymorphism (PCR-RFLP).
- Comparisons were made between 65 children with asthma and 68 healthy controls.
Main Results:
- Children with asthma exhibited significantly higher serum MMP-9 levels compared to healthy controls (P<0.05).
- No statistically significant differences were found in MMP-9 genotype or allele frequencies between asthmatic children and controls.
- Serum MMP-9 levels did not significantly differ among children with various MMP-9 genotypes.
Conclusions:
- Serum MMP-9 concentration is associated with the occurrence of childhood asthma.
- The MMP-9 -1562C/T gene polymorphism does not appear to be correlated with the pathogenesis of childhood asthma.
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