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Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Items for developing revised classification criteria in systemic sclerosis: Results of a consensus exercise.

Jaap Fransen¹, Sindhu R Johnson, Frank van den Hoogen

¹Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands.

Arthritis Care & Research

|November 5, 2011

Summary

Researchers updated systemic sclerosis (SSc) classification criteria using Delphi and nominal group techniques. Key items identified include skin thickening, autoantibodies, nailfold changes, and Raynaud's phenomenon for improved SSc diagnosis.

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Area of Science:

Rheumatology
Autoimmune Diseases
Clinical Classification

Background:

Systemic sclerosis (SSc), also known as scleroderma, requires updated classification criteria for accurate diagnosis and research.
Existing criteria may not fully capture the heterogeneity of SSc presentation and progression.

Purpose of the Study:

To identify and select items for a new classification system for systemic sclerosis (SSc).
To utilize consensus procedures, including Delphi and nominal group techniques (NGT), to refine potential classification items.

Main Methods:

Two independent consensus exercises identified 168 initial items.
A 3-round Delphi exercise and a nominal group technique (NGT) meeting involving SSc experts were conducted.
Items were rated for appropriateness and ranked to determine their utility in SSc classification.

Main Results:

An initial list of 168 items was reduced to 102, then 23 through expert consensus.
The highest-ranked items for SSc classification included skin thickening, SSc-specific autoantibodies, abnormal nailfold capillary patterns, and Raynaud's phenomenon.
The final set of 23 items also incorporated indicators of internal organ involvement.

Conclusions:

A consensus-driven set of 23 items was established for SSc classification.
These selected items will undergo further evaluation in a prospective study to assess their discriminative value.