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Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells
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Generation of Induced Regulatory T Cells from Primary Human Naïve and Memory T Cells

Published on: April 16, 2012

OMIP-004: in-depth characterization of human T regulatory cells

Angélique Biancotto1, Pradeep K Dagur, J Chris Fuchs

  • 1Center for Human Immunology, Autoimmunity, and Inflammation, National Institutes of Health, Bethesda, Maryland 28092, USA.

Cytometry. Part a : the Journal of the International Society for Analytical Cytology
|November 5, 2011
PubMed
Abstract

No abstract available in PubMed .

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T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

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