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Updated: May 27, 2026

Diagnosis of Neoplasia in Barrett’s Esophagus using Vital-dye Enhanced Fluorescence Imaging
Published on: May 11, 2014
Use of endoscopy with narrow-band imaging system in evaluating oral leukoplakia
Shih-Wei Yang1, Yun-Shien Lee, Liang-Che Chang
1Department of Otolaryngology-Head and Neck Surgery, Chang Gung Memorial Hospital, Keelung, Taiwan, Republic of China. sweeyang@gmail.com
Background:
The purpose of this study was to analyze the relationship between clinical features of oral leukoplakia using endoscopy with broadband white light, narrow-band imaging (NBI) illumination, and histopathology, and to discuss the clinical relevance of the NBI system.
Methods:
Clinicopathologic data of patients receiving biopsy or excision after endoscopic examination for leukoplakia from April 2009 to December 2010 were reviewed and analyzed statistically.
Results:
A total 154 patients, 130 men and 24 women (average age, 52.60 ± 10.86 years) were enrolled. The correlation between intraepithelium papillary capillary loop (IPCL) classification and stepwise increased severity of pathology (Pearson's r = .88, R(2) = 0.78) was significantly better than that of broadband white light images (p < .001).
Conclusions:
Flexible endoscopy can enhance detailed inspection of oral cavity mucosa and can be a powerful tool for examining oral leukoplakia. The IPCL patterns shown by NBI system can be helpful in detecting oral leukoplakia with higher grade dysplasia or invasive carcinoma.
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