Related Experiment Video
Updated: May 27, 2026

Extraction and Purification of Polyphenols from Freeze-dried Berry Powder for the Treatment of Vascular Smooth Muscle Cells In Vitro
Published on: July 5, 2017
Proanthocyanidins and other flavonoids in relation to pancreatic cancer: a case-control study in Italy
1Department of Epidemiology, Mario Negri Institute for Pharmacological Research, Milan, Italy. marta.rossi@marionegri.it
Background:
Four cohort studies have examined the relation between flavonoids and pancreatic cancer risk providing inconsistent results.
Patients And Methods:
We conducted a case-control study between 1991 and 2008 in Northern Italy. Subjects were 326 cases with incident pancreatic cancer and 652 frequency-matched controls (admitted to the same hospitals as cases for acute non-neoplastic conditions) who answered a reproducible and valid food-frequency questionnaire. We computed odds ratios (ORs) using logistic regression models conditioned on gender, age and study center, and adjusted for education, history of diabetes, tobacco smoking, alcohol drinking and energy intake.
Results:
Proanthocyanidins with three or more mers were inversely related to pancreatic cancer risk. The ORs were similar in all classes of polymers with three or more mers and in their combination (OR for the highest versus the lowest quintile of intake, 0.41; 95% confidence interval 0.24-0.69), and did not substantially change after adjustment for fruit and vegetable consumption, and for vitamin C and folate intakes. Eating an additional portion of fruits rich in proanthocyanidins every day reduced the risk of pancreatic cancer by 25%.
Conclusion:
Dietary proanthocyanidins-mostly present in apples, pears and pulses-may convey some protection against pancreatic cancer risk.
Related Concept Videos
Cancer Prevention
Some...
Cancer Prevention
Some...
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
Chronic Pancreatitis II: Pathophysiology
Chronic Pancreatitis I: Introduction

