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Updated: May 27, 2026
09:37
An Integrated Approach for Microprotein Identification and Sequence Analysis
Published on: July 12, 2022
SMART 7: recent updates to the protein domain annotation resource
Ivica Letunic1, Tobias Doerks, Peer Bork
1EMBL, Meyerhofstrasse 1, 69012 Heidelberg, Germany.
Nucleic Acids Research
|November 5, 2011
Summary
The Simple Modular Architecture Research Tool (SMART) database now offers enhanced protein domain analysis with expanded data and new features. This update improves protein domain identification and architecture analysis for researchers.
Area of Science:
- Bioinformatics
- Computational Biology
- Molecular Biology
Background:
- Protein domain identification and analysis are crucial for understanding protein function and evolution.
- Existing tools require updates to accommodate growing genomic data and user needs.
- The Simple Modular Architecture Research Tool (SMART) provides essential resources for protein research.
Purpose of the Study:
- To introduce SMART version 7, detailing its new features and expanded capabilities.
- To enhance protein domain annotation and analysis workflows.
- To improve accessibility and efficiency for researchers studying protein domain architectures.
Main Methods:
- Manual curation of protein domain models.
- Expansion of underlying protein databases and genome datasets.
- Development of new features including metaSMART and an advanced search engine.
Main Results:
- SMART version 7 includes 1009 manually curated protein domain models, a 2-fold increase in annotated domains and features.
- The database now covers 1133 sequenced genomes.
- New functionalities enhance domain architecture analysis, visualization, and metagenomics exploration.
Conclusions:
- SMART version 7 represents a significant advancement in protein domain analysis tools.
- The updated resource offers a faster, more comfortable workflow with expanded data coverage.
- New features like metaSMART cater to emerging research areas such as metagenomics.
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