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MimoDB 2.0: a mimotope database and beyond.

Jian Huang1, Beibei Ru, Ping Zhu

  • 1Key Laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, No 4, 2nd Section, North Jianshe Road, Chengdu, Sichuan 610054, China. hj@uestc.edu.cn

Nucleic Acids Research
|November 5, 2011
PubMed
Summary
This summary is machine-generated.

Mimotopes, peptides binding specific targets, are now cataloged in MimoDB 2.0. This database aids in developing diagnostics, therapeutics, and vaccines by organizing biopanning results.

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Area of Science:

  • Biochemistry
  • Bioinformatics
  • Immunology

Background:

  • Mimotopes are peptides with specific target affinities, crucial for understanding protein interactions and developing diagnostics, therapeutics, and vaccines.
  • Existing central databases like UniProt and NCBI GenPept do not curate mimotopes due to their short, 'unnatural' sequences.
  • MimoDB serves as a dedicated information portal for biopanning results from random peptide libraries.

Purpose of the Study:

  • To present MimoDB version 2.0, a comprehensive database of mimotopes.
  • To provide a valuable resource for researchers in diagnostics, therapeutics, and vaccine development.
  • To offer tools and benchmarks for bioinformaticians and experimental biologists.

Main Methods:

  • Collected 15,633 mimotopes from 849 scientific papers.
  • Organized peptides into 1818 distinct sets.
  • Integrated data on panning experiments, targets, templates, libraries, and structures.

Main Results:

  • MimoDB 2.0 contains 15,633 peptides from 849 publications, grouped into 1818 sets.
  • The database includes extensive background information on targets, templates, libraries, and structures.
  • A benchmark dataset is provided for developing and evaluating bioinformatics tools.

Conclusions:

  • MimoDB 2.0 is a vital resource for mimotope data, supporting research in diagnostics, therapeutics, and vaccines.
  • The database offers practical tools for experimental biologists, including virtual controls for target-unrelated peptide identification.
  • MimoDB enhances the accessibility and utility of mimotope information for the scientific community.