Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

Venous Thrombosis II: Clinical Manifestations and Diagnostic Studies

The key difference between Superficial Vein Thrombosis (SVT) and Deep Vein Thrombosis (DVT) lies in their location and severity.Clinical ManifestationsSVT typically presents with localized pain, tenderness, and redness along the course of a superficial vein, often accompanied by a palpable, cord-like structure under the skin. This condition is usually less dangerous than DVT but can be uncomfortable and may lead to complications such as cellulitis or, rarely, a clot extension into the deep...

Volume of Distribution

Volume of Distribution

The apparent volume of distribution (Vd) is a crucial pharmacokinetic parameter representing the hypothetical body fluid volume into which a drug disperses. It is calculated based on the total amount of drug in the body (estimated from the administered dose and bioavailability) divided by the plasma drug concentration. The total amount of drug in the body does not directly refer to the dose given but is derived by accounting for absorption, distribution, metabolism, and excretion processes.

Venous Thrombosis III: Interprofessional Care

Venous Thrombosis III: Interprofessional Care

Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...

Ischemic Stroke l: Introduction

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

Acute Coronary Syndrome III: Diagnostic Studies

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...

Ischemic Stroke ll: Pathophysiology

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Integrated sustainable valorization of seaweed (Ulva ohnoi) biomass into food-grade ingredients with year-round cultivated feedstock.

Bioresources and bioprocessing·2026

Same author

Optimization of serum-free medium supplemented with microalgal extract using response surface methodology for human fibroblast culture.

Journal of biological engineering·2026

Same author

Phytoplankton community responses to environmental changes in the Yellow Sea.

Marine environmental research·2025

Same author

Preparation of Highly Functional Spheroid of Endocrine Cells Based on Thermosensitive Glycol Chitosan.

Tissue engineering and regenerative medicine·2025

Same author

Serum-Free Medium Supplemented with <i>Haematococcus pluvialis</i> Extracts for the Growth of Human MRC-5 Fibroblasts.

Foods (Basel, Switzerland)·2024

Same author

Serum-Free Media Formulation Using Marine Microalgae Extracts and Growth Factor Cocktails for Madin-Darby Canine Kidney and Vero Cell Cultures.

International journal of molecular sciences·2024

Search research articles

Related Experiment Video

Updated: May 27, 2026

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

Correlation between Serum D-Dimer Level and Volume in Acute Ischemic Stroke.

Young-Woo Park¹, Eun-Jeong Koh, Ha-Young Choi

¹Department of Neurosurgery, Research Institute of Clinical Medicine, Chonbuk National University Medical School/Hospital, Jeonju, Korea.

Journal of Korean Neurosurgical Society

|November 5, 2011

Summary

Elevated D-dimer levels in acute ischemic stroke patients correlate positively with infarction volume. This finding suggests D-dimer can predict stroke severity and volume.

Keywords:

Acute ischemic stroke D-dimer Volume

More Related Videos

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

Related Experiment Videos

Last Updated: May 27, 2026

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis

Published on: June 2, 2015

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

Area of Science:

Neurology
Hematology
Biomarkers

Background:

D-dimer, a fibrin degradation product, is linked to stroke progression and type.
Previous research indicates a relationship between D-dimer levels and stroke outcomes.

Purpose of the Study:

To investigate the correlation between D-dimer levels and stroke volume in acute ischemic stroke patients.
To determine if D-dimer can serve as a predictive marker for infarction volume.

Main Methods:

Analysis of D-dimer levels in 59 acute ischemic stroke patients upon admission and after seven days.
Evaluation of National Institute of Health Stroke Scale, modified Rankin Scale, Glasgow outcome score, and infarction volume.

Main Results:

Mean D-dimer at admission was 626.6 µg/L, decreasing to 238.3 µg/L after seven days.
A positive correlation was observed between D-dimer levels and infarction volume (p=0.044).
Higher D-dimer levels at admission were associated with larger infarction volumes.

Conclusions:

D-dimer levels show a positive correlation with infarction volume in acute ischemic stroke.
D-dimer may be a useful biomarker for predicting stroke infarction volume.