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Related Experiment Video

Updated: May 27, 2026

Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade

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T cell depleted haploidentical transplantation: positive selection.

Franco Aversa¹

¹Pediatric Oncology/Hematology, BMT Unit, Section of Hematology, Department of Internal and Experimental Medicine, University of Perugia, Perugia, Italy.

Pediatric Reports

|November 5, 2011

Summary

One-haplotype mismatched transplants offer a readily available donor option for patients needing allogeneic transplants. This approach demonstrates excellent engraftment and low GVHD rates, comparing favorably with other stem cell sources.

Keywords:

T cell depleted haploidentical transplantation.

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Area of Science:

Immunology
Hematology
Transplantation Medicine

Background:

A significant unmet need exists for readily available stem cell donors for allogeneic transplantation.
One-haplotype mismatched donors are accessible for most patients, offering a timely alternative.

Purpose of the Study:

To review the advancements and outcomes of one-haplotype mismatched stem cell transplantation.
To evaluate the efficacy and safety of novel transplant techniques in this setting.

Main Methods:

Focus on conditioning regimens and post-transplant immunosuppression strategies.
Graft manipulation techniques, including megadose T cell-depleted or unmanipulated progenitor cells.
Analysis of engraftment rates, graft-versus-host disease (GVHD), and regimen-related mortality.

Main Results:

Excellent engraftment rates achieved in one-haplotype mismatched transplants.
Low incidence of both acute and chronic GVHD observed.
Favorable transplant-related mortality and event-free survival rates, even in older patients (>50 years).

Conclusions:

One-haplotype mismatched transplantation is a viable and effective strategy for patients lacking matched sibling donors.
Outcomes are comparable or superior to transplants from alternative stem cell sources.
This approach improves accessibility and survival for patients requiring urgent allogeneic transplants.