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Related Concept Videos

Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial exposure to a...
Hypersensitivity Reactions: Delayed Hypersensitivity Reactions01:29

Hypersensitivity Reactions: Delayed Hypersensitivity Reactions

Delayed-Type Hypersensitivity (DTH), or Type IV hypersensitivity, is a cell-mediated immune response. It occurs when T cells, rather than antibodies, mediate a reaction to specific antigens. It is characterized by a delayed onset (1-2 days) and involves the recruitment of macrophages to the inflammation site.The initiation of a DTH response begins with the sensitization of T cells. During this phase, which lasts at least 1-2 weeks, antigen-specific T cells are activated, clonally expanded, and...
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
Allergic Reactions02:06

Allergic Reactions

Overview
Allergic Drug Reactions01:27

Allergic Drug Reactions

Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing numerous...

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Related Experiment Video

Updated: May 27, 2026

Sieving Fruit Pulp to Detect Immature Tephritid Fruit Flies in the Field
04:21

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Hypersensitivity manifestations to the fruit mango.

Richa Sareen1, Ashok Shah

  • 1Department of Respiratory Medicine, Vallabhbhai Patel Chest Institute, University of Delhi, Delhi 110 007, India.

Asia Pacific Allergy
|November 5, 2011
PubMed
Summary
This summary is machine-generated.

Mango allergy can cause immediate or delayed hypersensitivity reactions, including oral allergy syndrome. Awareness is crucial as mango allergy can be severe and may occur even without prior mango exposure due to cross-reactivity.

Keywords:
AllergyAnaphylaxisContact dermatitisCross-reactivityMangoOral allergy syndromeUrticaria

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Area of Science:

  • Food Allergy and Immunology
  • Dermatology
  • Clinical Medicine

Background:

  • Mango (Mangifera indica) is a globally consumed fruit.
  • Allergic reactions to mango are increasingly recognized.
  • Understanding mango allergy manifestations is critical for patient care.

Purpose of the Study:

  • To consolidate current knowledge on mango allergy.
  • To delineate distinct clinical presentations of mango hypersensitivity.
  • To emphasize the significance of cross-reactivity and potential severe outcomes.

Main Methods:

  • Comprehensive literature search of Medline/PubMed and bibliographies.
  • Inclusion of key terms: mango, anaphylaxis, contact dermatitis, cross-reactivity, food hypersensitivity, oral allergy syndrome, urticaria.
  • Systematic review and synthesis of documented case reports.

Main Results:

  • Seventeen reports detailing 22 patients were analyzed.
  • Ten patients experienced immediate hypersensitivity reactions; twelve had delayed reactions.
  • Reactions occurred in both mango-cultivating regions and non-cultivating countries.

Conclusions:

  • Mango can induce both immediate and delayed hypersensitivity reactions, including oral allergy syndrome.
  • Severe, potentially life-threatening reactions to mango are possible.
  • Cross-reactivity can lead to reactions in individuals with no prior mango exposure, necessitating early recognition.