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Cervical conization--treatment for cervical intraepithelial neoplasia and carcinoma in situ
Z Perisic1, M Perisic, V P Karapandzic
1Department for Early Cancer Detection, Gynecology and Obstetrics Clinic "Narodni front", School of Medicine, Belgrade University, Belgrade, Serbia.
Purpose:
Cone biopsy is the best treatment for high-grade premalignant cervical changes. Cervical intraepithelial changes do not show any clinical picture until the process develops into carcinoma.
Method:
This retrospective study included 395 women who underwent conization at Gynecology and Obstetrics Clinic "Narodni front" during 2009. The chi-square test was used for comparing results.
Results:
Pathohistological findings from biospy and conization were identical in 40.50% of patients, in 10.13%, the conization finding was more severe than the biopsy finding, while in 49.37% less severe than the biopsy finding. Resection margins status analysis showed that 12.66% of cones were positive. Comparison between cones with positive margins and operative techniques did not show any statistically significant difference; 64% of women with positive margins were over the age of 35.
Conclusion:
Operative conization techniques are equally represented. However in women over the age of 40 scalpel excision methods are recommended. In women over the age of 45 there is a statistically significant increase in the risk for positive resection margin with CIN3 and glandular lesions.
