Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 27, 2026

Targeted Knockdown of Genes in the Choroid Plexus
04:43

Targeted Knockdown of Genes in the Choroid Plexus

Published on: June 16, 2023

Choroid plexus transport: gene deletion studies.

Richard F Keep1, David E Smith

  • 1Department of Neurosurgery, R5018 BSRB, University of Michigan, Ann Arbor, Michigan 48109-2200, USA. rkeep@umich.edu.

Fluids and Barriers of the CNS
|November 8, 2011
PubMed
Summary

Transporter knockout animals reveal choroid plexus (CP) function in the blood-cerebrospinal fluid barrier (BCSFB). This review details CP transporter roles and discusses the utility of knockout animal models.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Reward Deficiency Syndrome (RDS): A Common Neurogenetic Trait/State of All Addictions: Is this the new DSM?

British journal of healthcare and medical research·2026
Same author

Neurospirituality Connectome - Role in Neurology and Reward Deficiency Syndrome (RDS).

Neurology (E-Cronicon)·2025
Same author

Clinical evaluation of adults undergoing elective surgery utilizing intraoperative incisional wound irrigation (CLEAN Wound): protocol for a randomised controlled trial.

BMJ open·2025
Same author

Integrated Exposure-Response of Dupilumab in Children, Adolescents, and Adults With Atopic Dermatitis Using Categorical and Continuous Efficacy Assessments: A Population Analysis.

Pharmaceutical research·2023
Same author

Physiological Dynamics in the Upper Gastrointestinal Tract and the Development of Gastrointestinal Absorption Models for the Immediate-Release Oral Dosage Forms in Healthy Adult Human.

Pharmaceutical research·2023
Same author

Stochastic Differential Equation-based Mixed Effects Model of the Fluid Volume in the Fasted Stomach in Healthy Adult Human.

The AAPS journal·2023

Area of Science:

  • Neuroscience
  • Pharmacology
  • Physiology

Background:

  • The choroid plexus (CP) forms the blood-cerebrospinal fluid barrier (BCSFB), crucial for brain homeostasis.
  • Studies on CP transporter function, unlike the blood-brain barrier, are less common.
  • Key transporters at the CP include Pept2, ABC transporters, Oat3, and Svct2.

Purpose of the Study:

  • To review knowledge gained from transporter knockout (KO) animal studies on CP function.
  • To assess the role of the CP and its impact on brain parenchyma.
  • To discuss the advantages and disadvantages of using KO animals and relevant technical approaches.

Main Methods:

  • Literature review of studies utilizing transporter knockout animals.
  • Analysis of data concerning specific transporters (e.g., Pept2, ABC, Oat3, Svct2) at the CP.

More Related Videos

Induction of Protein Deletion Through In Utero Electroporation to Define Deficits in Neuronal Migration in Transgenic Models
12:01

Induction of Protein Deletion Through In Utero Electroporation to Define Deficits in Neuronal Migration in Transgenic Models

Published on: January 12, 2015

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

Related Experiment Videos

Last Updated: May 27, 2026

Targeted Knockdown of Genes in the Choroid Plexus
04:43

Targeted Knockdown of Genes in the Choroid Plexus

Published on: June 16, 2023

Induction of Protein Deletion Through In Utero Electroporation to Define Deficits in Neuronal Migration in Transgenic Models
12:01

Induction of Protein Deletion Through In Utero Electroporation to Define Deficits in Neuronal Migration in Transgenic Models

Published on: January 12, 2015

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations
08:22

A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations

Published on: December 1, 2017

  • Examination of the impact of CP transporter function on the brain parenchyma.

    • Main Results:

    • KO animal studies have elucidated the function of various transporters at the CP.
    • These studies highlight the CP's significant role in regulating the brain microenvironment.
    • Insights into the function of oligopeptide, organic anion, and ascorbic acid transporters have been gained.

    Conclusions:

    • Transporter KO animals are valuable tools for investigating CP function and BCSFB regulation.
    • Understanding CP transporter roles is essential for comprehending brain homeostasis and potential therapeutic interventions.
    • Further research using KO models can refine our understanding of the CP's contribution to neurological health.