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Updated: May 27, 2026

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Production and Targeting of Monovalent Quantum Dots
Published on: October 23, 2014
Synthesis of monomeric derivatives to probe memoquin's bivalent interactions
Maria Laura Bolognesi1, GianPaolo Chiriano, Manuela Bartolini
1Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, 40126 Bologna, Italy. marialaura.bolognesi@unibo.it
Journal of Medicinal Chemistry
|November 8, 2011
Abstract:
Eight monomeric congeners, related to the multitarget lead candidate memoquin, were prepared and evaluated at multiple targets to determine their profile against Alzheimer's disease. 2-4 bind to AChE with similar low nanomolar affinities and function as effective inhibitors of amyloid aggregation. The most potent monovalent ligand 2 also inhibits BACE-1 in vitro and APP metabolism in primary chicken telencephalic neurons.

