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Updated: May 27, 2026

Dopamine Release at Individual Presynaptic Terminals Visualized with FFNs
Published on: August 31, 2009
Neurotransmitter corelease: mechanism and physiological role
Thomas S Hnasko1, Robert H Edwards
1Departments of Physiology & Neurology, University of California, San Francisco, California 94158-2517, USA. thomas.hnasko@ucsf.edu
Abstract:
Neurotransmitter identity is a defining feature of all neurons because it constrains the type of information they convey, but many neurons release multiple transmitters. Although the physiological role for corelease has remained poorly understood, the vesicular uptake of one transmitter can regulate filling with the other by influencing expression of the H(+) electrochemical driving force. In addition, the sorting of vesicular neurotransmitter transporters and other synaptic vesicle proteins into different vesicle pools suggests the potential for distinct modes of release. Corelease thus serves multiple roles in synaptic transmission.
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