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Updated: May 27, 2026
07:25
A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
Targeting the androgen receptor--theory and practice.
Robert Dreicer1, Martin Gleave, Adam S Kibel
1Department of Solid Tumor Oncology; Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, USA.
Urology
|November 8, 2011
Summary
Recent advances improve understanding of androgen receptor biology and castrate-resistant prostate cancer. New hormonal therapies and better assays confirm ongoing testosterone suppression as the standard of care.
Area of Science:
- Oncology
- Endocrinology
- Molecular Biology
Background:
- The androgen receptor (AR) plays a crucial role in prostate cancer development and progression.
- Castrate-resistant prostate cancer (CRPC) remains a significant clinical challenge.
- Understanding AR biology has advanced significantly over the past two decades.
Purpose of the Study:
- To review the current knowledge of androgen receptor biology in prostate cancer.
- To discuss advancements in assessing disease progression and CRPC.
- To highlight the evolution of hormonal therapy and terminology in prostate cancer management.
Main Methods:
- Comprehensive literature review of studies on androgen receptor biology.
- Analysis of clinical data regarding disease progression assessment.
- Evaluation of the development and efficacy of novel hormonal therapy agents.
Main Results:
- Improved understanding of AR signaling pathways and their role in CRPC.
- Development of a new generation of hormonal therapy agents for androgen deprivation.
- Enhanced assays for monitoring disease progression and treatment response.
Conclusions:
- Ongoing suppression of testosterone is the established standard of care for prostate cancer.
- The terms "hormone-refractory" and "androgen-independent" prostate cancer should be reconsidered.
- Continued research into AR biology will likely yield further therapeutic advancements.
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