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Changes in CGRP-immunoreactive nerve fibres during experimental tooth movement in rats
1Department of Cariology and Endodontics, University of Bergen, Norway.
European Journal of Orthodontics
|August 1, 1990
Summary
Experimental tooth movement in rats increased calcitonin gene-related peptide (CGRP) nerves in the pulp and periodontium. These findings suggest CGRP-expressing nerves play a role in tissue responses during orthodontic tooth movement.
Area of Science:
- Neuroscience
- Dental Research
- Histology
Background:
- Calcitonin gene-related peptide (CGRP) is a neuropeptide involved in pain and inflammation.
- Nerve involvement in orthodontic tooth movement is not fully understood.
Purpose of the Study:
- To investigate changes in CGRP-expressing nerves in the periodontium and pulp during experimental mesial tooth movement.
- To elucidate the role of CGRP in tissue responses to orthodontic forces.
Main Methods:
- Immunohistochemistry was used to detect CGRP-immunoreactive (IR) nerve fibers.
- An orthodontic appliance applied continuous force to the first maxillary molar in rats.
- Tissue samples were analyzed after 5 days of force application.
Main Results:
- Mesial tooth movement induced changes in the number and morphology of CGRP-IR nerves.
- An increased number of CGRP-IR nerves was observed in the coronal pulp and periapical tissues of experimental teeth.
- Morphological alterations were noted in the nerve supply of experimental teeth and surrounding tissues.
Conclusions:
- Peptidergic nerve fibers expressing CGRP are actively involved in the tissue responses of the pulp and supporting tissues during experimental tooth movement.
- CGRP may play a significant role in the biological processes underlying orthodontic tooth movement.