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High-sensitivity C-reactive protein: a novel cardiovascular risk predictor in type 2 diabetics with normal lipid

Shilpa B Asegaonkar1, Amruta Marathe, Mangesh L Tekade

  • 1Department of Biochemistry, Government Medical College, Aurangabad, Maharashtra, India. b_asegaonkar@yahoo.com

Journal of Diabetes and Its Complications
|November 8, 2011
PubMed

Insights

High-sensitivity C-reactive protein (hs-CRP) is an independent predictor of cardiac risk in type 2 diabetes patients with normal lipid profiles. Elevated hs-CRP levels indicate increased cardiovascular risk, even without dyslipidemia.

Area of Science:

  • Cardiology
  • Endocrinology
  • Biochemistry

Background:

  • India has the highest prevalence of diabetes globally, with coronary heart disease being a leading cause of mortality among diabetic patients.
  • Type 2 diabetes mellitus and atherosclerosis share common inflammatory pathways.
  • High-sensitivity C-reactive protein (hs-CRP) is a marker of inflammation and a potential predictor of cardiac risk.

Purpose of the Study:

  • To investigate the role of hs-CRP as an independent cardiovascular risk marker in Indian patients with type 2 diabetes and normal lipid profiles.

Main Methods:

  • A case-control study was conducted with 60 type 2 diabetic patients (normal lipid profile) and 60 healthy controls.
  • Fasting blood samples were analyzed for hs-CRP and lipid profiles.
  • Unpaired t-test was used for statistical analysis.

Main Results:

  • Diabetic patients exhibited significantly higher hs-CRP levels (4.8 ± 0.2) compared to controls (0.9 ± 0.1).
  • A substantial proportion of diabetic patients were categorized into moderate-risk (1-3 mg/l) and high-risk (>3 mg/l) hs-CRP groups.
  • The odds ratio for cardiac risk was 10.23, indicating a significant association.

Conclusions:

  • hs-CRP serves as an independent predictor of cardiac risk in type 2 diabetes, even with a normal lipid profile.
  • Measuring hs-CRP can provide additional risk stratification for cardiovascular events.
  • Patients identified as intermediate or high risk based on hs-CRP may benefit from lifestyle interventions to prevent cardiovascular events.
Abstract

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