Related Experiment Video
Updated: May 27, 2026

07:59
Acetylcholine Re-Challenge After Intracoronary Nitroglycerine Administration
Published on: April 4, 2022
[Variant angina: what to think in 2011?]
X Halna du Fretay1, B Blanchard-Lemoine, B Schnebert
1Centre d'exploration cardiovasculaire, Orléans, France. xdufretay@orange.fr
Summary
Spastic angina, though rare, is likely underdiagnosed. New diagnostic guidelines are needed to improve the identification and treatment of this condition with a poor prognosis.
Area of Science:
- Cardiology
- Vascular Medicine
Background:
- Spastic angina, or coronary artery spasm, is an underrecognized cause of angina pectoris.
- Its prevalence may be underestimated, particularly in patients with underlying coronary atherosclerosis.
- Accurate diagnosis is crucial due to the condition's poor prognosis and specific therapeutic needs.
Observation:
- This report details three clinical cases of spastic angina, highlighting diverse presentations and diagnostic challenges.
- A literature review focused on diagnostic methods, especially provocative testing for coronary spasm.
- Current provocative testing protocols require adaptation to modern coronary angiography techniques, including the prevalent radial approach.
Findings:
- Existing diagnostic criteria and methods for spastic angina, particularly provocative testing, are outdated.
- There is a need for updated recommendations for provocative testing and clear diagnostic criteria.
- These criteria should integrate clinical, electrocardiographic, and angiographic data.
Implications:
- Revised guidelines for provocative testing and diagnosis are essential for clinical practice.
- Improved diagnostic accuracy can lead to better management and treatment of spastic angina patients.
- Standardized diagnostic approaches will enhance the recognition of this potentially serious condition.
Related Concept Videos
Angina II: Classification
Angina, also known as angina pectoris, is a chest pain resulting from diminished blood flow to the heart muscle and is often a symptom of coronary artery disease. Angina presents several variants with distinctive attributes, etiologies, and therapeutic approaches. The main types of angina include stable, unstable, variant (Prinzmetal's), microvascular, intractable, and silent ischemia.Stable angina is caused by atherosclerosis, which leads to the formation of plaques that narrow the coronary...
Angina III: Clinical Manifestations and Assessment
Angina manifests as chest pain, tightness, or squeezing discomfort typically located behind the breastbone. It can radiate to the neck, jaw, shoulders, and inner aspects of the upper arms, most commonly the left arm. Patients may experience shortness of breath, fatigue, profuse sweating, dizziness, indigestion, heartburn, palpitations, anxiety, and vomiting as accompanying symptoms. This pain often lasts a few minutes and is triggered by physical exertion, emotional stress, heavy meals, or cold...
Angina IV: Management
IntroductionThe management of angina requires a comprehensive approach that includes pharmacological therapies, medical procedures, and lifestyle modifications.Pharmacological TherapiesAntiplatelet agents, such as aspirin, clopidogrel, prasugrel, and ticagrelor, play a pivotal role in preventing thrombus formation in patients with angina. These medications inhibit platelet aggregation and reduce the likelihood of myocardial infarction and other cardiovascular events.Anticoagulants, including...
Angina I: Introduction
Definition and Symptoms: Angina (angina pectoris) is chest pain or discomfort caused by myocardial ischemia, which occurs when the heart muscle receives insufficient oxygen-rich blood. It typically manifests as pressing, squeezing, or crushing sensations in the chest and may radiate to the shoulders, arms, neck, jaw, or back.Primary Cause: In a healthy state, the coronary arteries can dilate (widen) to increase blood flow and meet the increased oxygen demand during physical activity or...
Angina V: Nursing Management
Angina, a symptom of myocardial ischemia, requires a structured nursing management approach to ensure effective care and prevent complications like myocardial infarction. Comprehensive nursing care involves assessing, diagnosing, planning, implementing interventions, and evaluating outcomes, all tailored to the individual patient's needs.Patient AssessmentNursing assessment begins with a detailed subjective evaluation of symptoms, which typically include chest pain or pressure radiating to the...
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...

