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Related Concept Videos

Methods of Nuclear Reprogramming01:24

Methods of Nuclear Reprogramming

Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for injury repair.
Introduction to Nuclear Reprogramming01:14

Introduction to Nuclear Reprogramming

Nuclear reprogramming is the process of switching gene expression of one cell type to that of another cell type, usually from a differentiated cell state to an undifferentiated cell state. Differentiation occurs during processes such as development and morphogenesis, tissue regeneration, and malignancy. Cells can also be artificially induced to reprogram their gene expression by techniques such as nuclear transfer, induced pluripotency, and cell fusion. Such techniques have many applications in...
Directionality of Nuclear Transport01:42

Directionality of Nuclear Transport

Ras-related nuclear protein or Ran is a small G protein that cycles between its GTP and GDP bound states. Ran specific regulators, a Ran GTPase Activating Protein or RanGAP present in the cytosol and a Ran guanine nucleotide exchange factor or RanGEF present inside the nucleus regulate GTP/GDP exchange. A high concentration of GTP inside the cells, in addition to this asymmetric distribution of  Ran-specific regulators, leads to a higher RanGTP concentration inside the nucleus. This...
Nuclear Export01:42

Nuclear Export

The nucleus restricts several proteins within and allows others to pass. The restricted proteins possess a nuclear retention sequence or NRS, anchoring them to the nuclear lamins and preventing their transport to the cytosol. The non-restricted proteins, after their synthesis, are transported to their site of action, such as the cytosol or other organelles, with the help of nuclear export signals or NES.
NES are of three types- the canonical 10-residue long leucine-rich signal and other...
Nuclear Overhauser Enhancement (NOE)01:06

Nuclear Overhauser Enhancement (NOE)

Irradiation of a spin-active nucleus causes an increase or decrease in the signal intensity of neighboring nuclei that are not necessarily chemically bonded or involved in J-coupling. This phenomenon, called the nuclear Overhauser enhancement (NOE), results from through-space interactions between the nuclear spins. The NOE effect decreases with increasing internuclear distance and is generally not observed beyond 4 angstroms. In NOE, dipole-dipole interactions between neighboring spin-active...
Nuclear Localization Signals and Import01:46

Nuclear Localization Signals and Import

Proteins targeted to the nucleus carry short stretches of amino acid sequences called the nuclear localization signal or NLS. Classical nuclear localization signals are of two types: monopartite and bipartite NLS. Monopartite classical NLS (cNLS) consists of a single cluster of 4-8 amino acids. Bipartite cNLS consists of two clusters of  2-3 amino acids and a 9-12 residue long proline-rich linker bridging the two clusters. Signal clusters are rich in positively charged amino acids such as...

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Related Experiment Video

Updated: May 27, 2026

A Versatile Pipeline for Analyzing Dynamic Changes in Nuclear Bodies in a Variety of Cell Types
06:33

A Versatile Pipeline for Analyzing Dynamic Changes in Nuclear Bodies in a Variety of Cell Types

Published on: June 28, 2024

Nuclear norm-regularized SENSE reconstruction.

Angshul Majumdar1, Rabab K Ward

  • 1Department of Electrical and Computer Engineering, University of British Columbia, Vancouver, Canada. angshulm@ece.ubc.ca

Magnetic Resonance Imaging
|November 8, 2011
PubMed
Summary
This summary is machine-generated.

This study introduces a faster magnetic resonance imaging (MRI) reconstruction method. By exploiting image rank deficiency instead of transform domain sparsity, the new technique offers comparable accuracy to Compressed Sensing (CS)-SENSE but is significantly quicker.

Related Experiment Videos

Last Updated: May 27, 2026

A Versatile Pipeline for Analyzing Dynamic Changes in Nuclear Bodies in a Variety of Cell Types
06:33

A Versatile Pipeline for Analyzing Dynamic Changes in Nuclear Bodies in a Variety of Cell Types

Published on: June 28, 2024

Area of Science:

  • Medical Imaging
  • Biophysics
  • Signal Processing

Background:

  • SENSitivity Encoding (SENSE) is an optimal parallel MRI technique when coil sensitivities are known.
  • Compressed Sensing (CS) enhances SENSE by leveraging image sparsity in a transform domain, typically using l(1)-norm regularization.

Purpose of the Study:

  • To develop a novel SENSE reconstruction method that exploits image rank deficiency.
  • To compare the reconstruction accuracy and computational speed of the proposed method against existing CS-based techniques.

Main Methods:

  • Developed a nuclear norm-regularized SENSE reconstruction framework.
  • Exploited the low-rank property of MR images for reconstruction.

Main Results:

  • Achieved reconstruction accuracy comparable to l(1)-norm-regularized SENSE.
  • Demonstrated a computational speed improvement of approximately one order of magnitude.

Conclusions:

  • Exploiting image rank deficiency offers a computationally efficient alternative for SENSE reconstruction.
  • The nuclear norm-regularized approach provides a faster yet accurate method for parallel MRI image recovery.