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Related Concept Videos

Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
Introduction to Special Senses01:26

Introduction to Special Senses

Sensory receptors play an integral part in comprehending our external and internal environments. They receive diverse stimuli, converting them into the nervous system's electrochemical signals. This conversion occurs as the stimulus alters the sensory neuron's cell membrane potential, instigating the generation of an action potential. This action potential is subsequently transmitted to the central nervous system (CNS), which integrates with other sensory data or higher cognitive functions.
Electro-mechanical Systems01:19

Electro-mechanical Systems

Electromechanical systems are intricate configurations that effectively combine electrical and mechanical elements to achieve a desired outcome. Central to many of these systems is the DC motor, a device that converts electrical energy into mechanical motion, enabling various applications ranging from simple fans to complex robotic mechanisms.
A key component of the DC motor is the armature, a rotating circuit positioned within a magnetic field. As an electric current passes through the...
Tactile and Chemical Senses01:27

Tactile and Chemical Senses

Tactile senses encompass touch, temperature, and pain, each mediated by specific receptors. Touch receptors detect mechanical energy or pressure against the skin. Sensory fibers from these receptors enter the spinal cord and relay information to the brain stem. Here, most fibers cross over to the opposite side of the brain. The touch information then moves to the thalamus, which projects a map of the body's surface onto the somatosensory areas of the parietal lobes in the cerebral cortex. This...
Somatosensation01:33

Somatosensation

The somatosensory system relays sensory information from the skin, mucous membranes, limbs, and joints. Somatosensation is more familiarly known as the sense of touch. A typical somatosensory pathway includes three types of long neurons: primary, secondary, and tertiary. Primary neurons have cell bodies located near the spinal cord in groups of neurons called dorsal root ganglia. The sensory neurons of ganglia innervate designated areas of skin called dermatomes.

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Related Experiment Video

Updated: May 27, 2026

A Behavioral Assay for Mechanosensation of MARCM-based Clones in Drosophila melanogaster
05:48

A Behavioral Assay for Mechanosensation of MARCM-based Clones in Drosophila melanogaster

Published on: December 30, 2015

Noxious mechanosensation - molecules and circuits.

John N Wood1, Niels Eijkelkamp

  • 1Wolfson Institute for Biomedical Research, University College London, London WC1E 6BT, UK. J.Wood@ucl.ac.uk

Current Opinion in Pharmacology
|November 8, 2011
PubMed
Summary

New analgesic drug strategies may emerge from understanding how sensory neurons detect mechanical pain. Research focuses on identifying specific channels, cell types, and neural pathways involved in mechanosensation for pain relief.

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Measurement of Vibration Detection Threshold and Tactile Spatial Acuity in Human Subjects
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Measurement of Vibration Detection Threshold and Tactile Spatial Acuity in Human Subjects

Published on: September 1, 2016

Related Experiment Videos

Last Updated: May 27, 2026

A Behavioral Assay for Mechanosensation of MARCM-based Clones in Drosophila melanogaster
05:48

A Behavioral Assay for Mechanosensation of MARCM-based Clones in Drosophila melanogaster

Published on: December 30, 2015

Measurement of Vibration Detection Threshold and Tactile Spatial Acuity in Human Subjects
07:32

Measurement of Vibration Detection Threshold and Tactile Spatial Acuity in Human Subjects

Published on: September 1, 2016

Area of Science:

  • Neuroscience
  • Pharmacology
  • Pain Research

Background:

  • Mechanically-evoked pain is a common condition lacking effective drug targets.
  • Peripheral sensory neuron properties, including molecular expression and wiring, influence pain sensation.
  • Recent advancements have improved understanding of mechanosensation mechanisms.

Purpose of the Study:

  • To identify potential drug development targets for blocking mechanically-evoked pain.
  • To explore the roles of specific mechano-transducing channels in pain pathways.
  • To investigate relevant cell types and neural circuits for analgesic strategies.

Main Methods:

  • Review of recent scientific literature on mechanosensation and pain.
  • Analysis of molecular and cellular mechanisms underlying mechanical pain transduction.
  • Examination of peripheral and central nervous system pathways involved in mechanosensation.

Main Results:

  • Identification of key mechano-transducing channels as potential drug targets.
  • Characterization of specific sensory neuron populations involved in mechanical pain.
  • Elucidation of neural wiring patterns relevant to mechanical pain signaling.

Conclusions:

  • Understanding mechanosensation pathways offers novel opportunities for analgesic drug development.
  • Targeting specific mechano-transducing channels could lead to effective pain relief therapies.
  • Further research into sensory neuron biology is crucial for advancing pain management.