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Updated: May 27, 2026

Capturing the Cardiac Injury Response of Targeted Cell Populations via Cleared Heart Three-Dimensional Imaging
Published on: March 17, 2020
Rewind to recover: dedifferentiation after cardiac injury
1Department of Medicine and Department of Cell and Developmental Biology, Institute for Regenerative Medicine, Cardiovascular Institute, Translational Research Center, University of Pennsylvania, Philadelphia, PA 19104-5129, USA. emorrise@mail.med.upenn.edu
Abstract:
In adult mammals, cardiomyocytes are known to reactivate an embryonic gene-expression program after injury. In this issue of Cell Stem Cell, Kubin et al. (2011) show that oncostatin M regulates this dedifferentiation which, while beneficial for recovery from acute injury, if persistent results in heart failure in both rodents and humans.
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