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DNA Microarrays

DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...

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Protein Glycosylation

Glycosylation, the most common post-translational modification for proteins, serves diverse functions. Adding sugars to proteins makes the proteins more resistant to proteolytic digestion. Glycosylated proteins can act as markers and receptors to promote cell-cell adhesion. Additionally, they have many essential quality control functions in the cell, such as correct protein folding and facilitating transport of misfolded proteins to the cytosol, which can be degraded.
Glycosylation occurs in...

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Related Experiment Video

Updated: May 27, 2026

Profiling Anti-Neu5Gc IgG in Human Sera with a Sialoglycan Microarray Assay

Profiling Anti-Neu5Gc IgG in Human Sera with a Sialoglycan Microarray Assay

Published on: July 13, 2017

Recent advances and future challenges in glycan microarray technology.

José L de Paz¹, Peter H Seeberger

¹Instituto de Investigaciones Químicas, Centro de Investigaciones Científicas Isla de la Cartuja, CSIC and US, Sevilla, Spain. jlpaz@iiq.csic.es

Methods in Molecular Biology (Clifton, N.J.)

|November 8, 2011

Summary

Glycan microarrays enable efficient study of biomolecule-carbohydrate interactions. This technology offers parallel screening, minimal sample use, and natural sugar presentation for glycomics and drug discovery.

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Microarray Polymer Profiling (MAPP) for High-Throughput Glycan Analysis

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Last Updated: May 27, 2026

Profiling Anti-Neu5Gc IgG in Human Sera with a Sialoglycan Microarray Assay

Profiling Anti-Neu5Gc IgG in Human Sera with a Sialoglycan Microarray Assay

Published on: July 13, 2017

Printed Glycan Array: A Sensitive Technique for the Analysis of the Repertoire of Circulating Anti-carbohydrate Antibodies in Small Animals

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Microarray Polymer Profiling (MAPP) for High-Throughput Glycan Analysis

Microarray Polymer Profiling (MAPP) for High-Throughput Glycan Analysis

Published on: September 29, 2023

Area of Science:

Carbohydrate chemistry
Biotechnology
Glycomics

Background:

Glycan microarrays are essential tools for studying carbohydrate interactions.
They offer high-throughput screening and mimic natural carbohydrate presentation.

Purpose of the Study:

To present recent advances in glycan microarray technology.
To discuss future challenges and applications in various scientific fields.

Main Methods:

Utilizing chip-based formats for parallel screening of thousands of binding events.
Employing diverse immobilization and detection strategies for glycan analysis.

Main Results:

Demonstrated the advantages of glycan microarrays, including minimal sample requirements.
Highlighted the multivalent display of sugars, mimicking natural biological contexts.

Conclusions:

Glycan microarray technology continues to advance, offering significant potential.
Applications span glycomics, drug discovery, and biomedicine, with ongoing challenges to address.