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Related Experiment Video

Updated: May 27, 2026

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant

Published on: May 27, 2011

Virus-like particles induce robust human T-helper cell responses.

Marion Braun¹, Camilla Jandus, Patrik Maurer

¹Ludwig Center for Cancer Research of University of Lausanne, Switzerland.

European Journal of Immunology

|November 8, 2011

Summary

Virus-like particles (VLPs) show potential for strong antibody and T-cell responses. This study analyzed CD4(+) T-cell responses to a VLP vaccine, demonstrating its capacity to induce both humoral and cellular immunity.

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Detection of Neutralization-sensitive Epitopes in Antigens Displayed on Virus-Like Particle (VLP)-Based Vaccines Using a Capture Assay

Detection of Neutralization-sensitive Epitopes in Antigens Displayed on Virus-Like Particle (VLP)-Based Vaccines Using a Capture Assay

Published on: February 10, 2022

Area of Science:

Immunology
Vaccinology
Synthetic Biology

Background:

Virus-like particles (VLPs) are recognized for inducing robust humoral immunity.
Understanding VLP-induced CD4(+) T-cell responses is crucial for optimizing antibody isotype switching and CD8(+) T-cell vaccination strategies.

Purpose of the Study:

To analyze human CD4(+) T-cell responses to a novel VLP vaccine (MelQbG10).
To evaluate the vaccine's capacity to elicit both humoral and cellular immunity against viral and tumor-associated antigens.

Main Methods:

Vaccination of patients with MelQbG10, a Qβ-VLP linked to a Melan-A peptide.
Analysis of antibody isotypes (IgG1, IgG3) and CD4(+) T-cell responses specific to Qβ and Melan-A.

Main Results:

Strong antibody responses, predominantly IgG1 and IgG3, were observed.
Concomitant Th1-biased CD4(+) T-cell responses specific for Qβ were detected.
Comparable, though less potent, B-cell and CD4(+) T-cell responses were also elicited against the Melan-A peptide.

Conclusions:

The MelQbG10 VLP vaccine effectively induces humoral and cellular immune responses.
VLPs demonstrate significant potential for mounting powerful CD4(+) T-cell help, essential for comprehensive vaccine efficacy.
Further optimization is needed to enhance responses directed towards the cargo peptide (Melan-A).