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Updated: May 27, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
Improving patient care through implementation of an antimicrobial stewardship program.
Hannah R Palmer1, Jaye Weston, Layne Gentry
1St. Luke’s Episcopal Hospital, Houston, TX, USA.
Implementing an antimicrobial stewardship program (ASP) at a health system reduced inappropriate antibiotic use. This initiative improved patient care, advanced clinical research, and enhanced training for infectious diseases pharmacists.
Area of Science:
- Infectious Diseases
- Health Services Research
- Pharmacy Practice
Background:
- Antimicrobial resistance necessitates optimized antibiotic use.
- Effective antimicrobial stewardship programs (ASPs) are crucial for patient outcomes and public health.
- The Center for Antimicrobial Stewardship and Epidemiology (CASE) was established to address these needs.
Purpose of the Study:
- To describe the implementation of an ASP at St. Luke's Episcopal Hospital (SLEH).
- To outline the structure and aims of the CASE program.
- To highlight the program's impact on patient care, research, and education.
Main Methods:
- Formation of the CASE team, including infectious diseases pharmacists and a physician medical director.
- Development and implementation of antimicrobial stewardship and management policies.
- Integration of clinical problem identification, research, and policy change.
Main Results:
- Decreased inappropriate antibiotic utilization.
- Improved patient care and clinical outcomes.
- Enhanced opportunities for clinical research and pharmacist training.
Conclusions:
- The implemented ASP successfully reduced inappropriate antibiotic use.
- The program contributed to better patient care, advanced clinical research, and expanded training for infectious diseases pharmacists.
- The CASE model provides a framework for effective antimicrobial stewardship in healthcare systems.
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