Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Video

Updated: May 27, 2026

Meal Duration as a Measure of Orofacial Nociceptive Responses in Rodents

Meal Duration as a Measure of Orofacial Nociceptive Responses in Rodents

Published on: January 10, 2014

Rapid estrogenic effects on TMJ-responsive brainstem neurons.

A Tashiro¹, K Okamoto, D A Bereiter

¹Dept. of Diagnostic and Biological Sciences, University of Minnesota School of Dentistry, Minneapolis, MN 55455, USA.

Journal of Dental Research

|November 8, 2011

Summary

Estrogen rapidly modulates temporomandibular joint pain signals in the brainstem. This study reveals non-genomic estrogen actions influencing craniofacial pain processing.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Estrogen Status and Trigeminal Ganglion Responses to Jaw Movement.

Journal of dental research·2022

Same author

A critical period for antidepressant-induced acceleration of neuronal maturation in adult dentate gyrus.

Translational psychiatry·2017

Same author

Cephalic phase, reflex insulin secretion neuroanatomical and physiological characterization.

Diabetologia·2016

Same author

CNS modulation of pancreatic endocrine function : Multiple modes of expression.

Diabetologia·2016

Same author

Local group I mGluR antagonists reduce TMJ-evoked activity of trigeminal subnucleus caudalis neurons in female rats.

Neuroscience·2015

Same author

Inhibition of temporomandibular joint input to medullary dorsal horn neurons by 5HT3 receptor antagonist in female rats.

Neuroscience·2015

Area of Science:

Neuroscience
Endocrinology
Pain Research

Background:

Estrogen status influences temporomandibular muscle and joint disorders (TMJD) and craniofacial pain.
Estrogen's pain modulation mechanisms are not fully understood, often attributed to genomic effects.
Estrogens can rapidly affect neural activity via membrane-initiated pathways.

Purpose of the Study:

To investigate if estrogens rapidly modulate TMJ-responsive neurons.
To determine the brainstem region involved in rapid estrogenic effects on TMJ sensory signals.

Main Methods:

Applied 17β-estradiol (E2) to the spinomedullary (Vc/C(1-2)) region in ovariectomized rats.
Recorded single neuron activity in response to TMJ stimulation.
Utilized estrogen receptor (ER) subtype agonists and a membrane-impermeable E2 analogue (E(2)-BSA).

More Related Videos

Temporomandibular Joint Pain Measurement by Bite Force and Von Frey Filament Assays in Mice

Temporomandibular Joint Pain Measurement by Bite Force and Von Frey Filament Assays in Mice

Published on: September 13, 2024

Controlled Cortical Impact Model for Traumatic Brain Injury

Controlled Cortical Impact Model for Traumatic Brain Injury

Published on: August 5, 2014

Related Experiment Videos

Last Updated: May 27, 2026

Meal Duration as a Measure of Orofacial Nociceptive Responses in Rodents

Meal Duration as a Measure of Orofacial Nociceptive Responses in Rodents

Published on: January 10, 2014

Temporomandibular Joint Pain Measurement by Bite Force and Von Frey Filament Assays in Mice

Temporomandibular Joint Pain Measurement by Bite Force and Von Frey Filament Assays in Mice

Published on: September 13, 2024

Controlled Cortical Impact Model for Traumatic Brain Injury

Controlled Cortical Impact Model for Traumatic Brain Injury

Published on: August 5, 2014

Main Results:

E2 rapidly (within 10 minutes) and reversibly reduced TMJ-evoked neural activity in the Vc/C(1-2) region.
ERβ agonists inhibited, while an ERα agonist enhanced, evoked activity, indicating ER subtype specificity.
The membrane-impermeable E(2)-BSA mimicked E2's inhibitory effect, suggesting a membrane-mediated mechanism.

Conclusions:

Estrogen rapidly modulates TMJ sensory signals at the Vc/C(1-2) brainstem region via membrane-mediated pathways.
These findings support the hypothesis that estrogens act quickly in the trigeminal brainstem complex to influence TMJ pain integration.