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d-AMPHETAMINE AS A PREDICTOR FOR RESPONSE TO IMIPRAMINE AND AMITRIPTYLINE.

A A Quadri1, K Shalini, S M Channabasavanna

  • 1Lecturer in Psychiatry, SRTR Medical College Hospital, Ambajogai, Maharastra.

Indian Journal of Psychiatry
|November 8, 2011
PubMed
Summary
This summary is machine-generated.

This study found that patients with endogenous depression who improved with d-amphetamine also responded to tricyclic antidepressants. Non-responders to d-amphetamine did not improve with tricyclics, suggesting a potential link in treatment response.

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Area of Science:

  • Clinical Psychiatry
  • Pharmacology
  • Neuroscience

Background:

  • Endogenous depression is a significant psychiatric condition requiring effective treatment.
  • Assessing treatment response in depression is crucial for patient outcomes.
  • D-amphetamine and tricyclic antidepressants are established treatments for depression.

Purpose of the Study:

  • To investigate the relationship between treatment response to d-amphetamine and tricyclic antidepressants in patients with endogenous depression.
  • To determine if improvement with d-amphetamine predicts response to tricyclic therapy.

Main Methods:

  • A clinical trial involving patients diagnosed with endogenous depression based on Feighner's criteria.
  • Patients had baseline scores above 20 on Hamilton's depression rating scale.
  • Participants were assigned to groups receiving placebo, d-amphetamine, or tricyclic antidepressants.

Main Results:

  • All patients who showed improvement with d-amphetamine also demonstrated improvement when treated with tricyclic antidepressants.
  • Two patients who did not respond to d-amphetamine also did not respond to tricyclic antidepressants.
  • This suggests a correlation in treatment efficacy between the two drug classes.

Conclusions:

  • Treatment response to d-amphetamine may indicate a similar response to tricyclic antidepressants in endogenous depression.
  • These findings could inform treatment selection for patients with endogenous depression.
  • Further research is warranted to explore the shared mechanisms of action.