Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypothyroidism II: Pathophysiology01:23

Hypothyroidism II: Pathophysiology

Hypothyroidism is a disorder characterized by insufficient production of thyroid hormones, which regulate metabolism, energy balance, and multiple organ systems.TypesHypothyroidism is classified based on the level of dysfunction. Primary hypothyroidism results from intrinsic thyroid gland dysfunction, causing reduced hormone production despite normal or increased stimulation. Secondary hypothyroidism arises from inadequate thyroid-stimulating hormone (TSH) secretion by the pituitary. Tertiary...
Depression: Overview01:18

Depression: Overview

Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The iodine is then...
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
Hyperthyroidism II: Pathophysiology01:27

Hyperthyroidism II: Pathophysiology

Hyperthyroidism is a hypermetabolic state caused by elevated levels of thyroid hormones, triiodothyronine (T3) and thyroxine (T4). It results from dysregulation at the thyroid, pituitary, or immune system level and affects multiple organ systems.PathophysiologyThe most common cause of hyperthyroidism is Graves’ disease, an autoimmune disorder in which antibodies, specifically thyroid-stimulating antibodies (TSAb), a subtype of TSH receptor antibodies (TRAb), bind to and activate TSH receptors...
Depressive Disorders: MDD and Dysthymia01:27

Depressive Disorders: MDD and Dysthymia

Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Outcomes of immune-checkpoint inhibitor rechallenge in metastatic clear-cell renal cell carcinoma: results from a global real-world evidence study.

ESMO open·2026
Same author

Outcomes of immune checkpoint inhibitor rechallenge in advanced urothelial carcinoma: results from a global real-world evidence study.

ESMO open·2025
Same author

Circulating kidney injury molecule-1 (KIM-1) and association with outcome to adjuvant immunotherapy in renal cell carcinoma.

Annals of oncology : official journal of the European Society for Medical Oncology·2025
Same author

Multicenter analysis of high-dose chemotherapy regimens for the treatment of patients with refractory or recurrent germ cell tumors.

ESMO open·2025
Same author

Polarity-sensitive dual emissive fluorescent carbon dots as highly specific targeting probes for lipid droplets in live cells.

Nanoscale advances·2025
Same author

First-in-human phase I study to evaluate safety, tolerability, pharmacokinetics, pharmacodynamics, immunogenicity, and antitumor activity of PF-07209960 in patients with advanced or metastatic solid tumors.

ESMO open·2025
Same journal

Exploring the relationship between snake bites and post-traumatic stress disorder: A prospective study on associated factors.

Indian journal of psychiatry·2026
Same journal

Non-invasive brain stimulation as an experimental treatment approach for bulimia nervosa and binge eating disorders: A meta-analysis and systematic review of literature.

Indian journal of psychiatry·2026
Same journal

Re-examining the severity classification utility of the Indian scale for assessment of autism in children with autism having co-morbid conditions.

Indian journal of psychiatry·2026
Same journal

How clinicians think about dual disorders: Insights from a case vignette survey.

Indian journal of psychiatry·2026
Same journal

Teaching and shaping young minds: Perspectives of south Indian medical students on psychiatry education- An online survey.

Indian journal of psychiatry·2026
Same journal

Cognitive and emotional empathy in schizophrenia as State-independent impairment: A multidimensional task paradigm study.

Indian journal of psychiatry·2026
See all related articles

Related Experiment Video

Updated: May 27, 2026

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
04:33

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Published on: April 26, 2024

Thyroid function in depression.

G C Boral1, A B Ghosh, S K Pal

  • 1University College of Medicine, University of Calcutta.

Indian Journal of Psychiatry
|November 8, 2011
PubMed
Summary
This summary is machine-generated.

This study found that patients with depression exhibit lower thyroid hormone levels (T3 and T4) and higher thyroid-stimulating hormone (TSH). Female patients displayed notably reduced thyroid function compared to males.

More Related Videos

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model
08:15

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Published on: June 6, 2025

Related Experiment Videos

Last Updated: May 27, 2026

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
04:33

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder

Published on: April 26, 2024

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model
08:15

Network Pharmacology and Validation of the Antidepressant Mechanisms of Qiangzhifang in a Chronic Restraint Stress-induced Depression Rat Model

Published on: June 6, 2025

Area of Science:

  • Endocrinology
  • Psychiatry
  • Neuroscience

Background:

  • Thyroid dysfunction is increasingly recognized as a potential factor in mood disorders.
  • Depression is a complex condition with multifactorial etiologies, including potential neuroendocrine links.

Purpose of the Study:

  • To investigate thyroid function in patients diagnosed with depression.
  • To compare thyroid hormone levels between depressed patients and a healthy control group.
  • To explore potential sex-based differences in thyroid function among depressed individuals.

Main Methods:

  • Thyroid function tests were conducted on 31 patients with depression.
  • Hormone levels including triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH) were measured.
  • Data were compared between the depressed cohort and a normal control group, with further subgroup analysis by sex.

Main Results:

  • Depressed patients showed significantly diminished levels of T3 and T4.
  • A concomitant rise in TSH levels was observed in the depressed group.
  • Female patients with depression exhibited a significantly lower thyroid functional status compared to male patients.

Conclusions:

  • Depression is associated with altered thyroid function, characterized by reduced T3 and T4 and elevated TSH.
  • These findings suggest a potential role for thyroid dysfunction in the pathophysiology of depression.
  • Sex-specific differences in thyroid function may influence the presentation or severity of depression.