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Growth increments with low dose intermittent growth hormone and fluoxymesterone in first year of therapy in

R T Kirkland, G W Clayton

    Pediatrics
    |March 1, 1979
    PubMed

    Insights

    A lower dose of human growth hormone (hGH) combined with fluoxymesterone effectively improved growth in children with hypopituitarism. This intermittent regimen offers a cost-effective treatment option without accelerating bone age.

    Area of Science:

    • Pediatric Endocrinology
    • Growth Hormone Therapy

    Background:

    • Commercial human growth hormone (hGH) availability enables exploring optimized treatment protocols.
    • Hypopituitarism in children necessitates effective growth hormone replacement therapy.

    Purpose of the Study:

    • To evaluate the efficacy of a lower, intermittent dose of hGH in children with hypopituitarism.
    • To assess the impact of this regimen on growth velocity and bone age.

    Main Methods:

    • Thirteen children (ages 4-13) received intramuscular hGH (1 IU daily for 12-36 days/course, 4 courses/year) with oral fluoxymesterone (1-2 mg).
    • Total annual hGH dose ranged from 48-112 IU, significantly lower than standard regimens (312 IU/year).

    Main Results:

    • All 13 children demonstrated improved growth velocity, averaging 6.4 cm ± 1.13 SD.
    • The mean bone age advancement was 0.57 years ± 0.14 SEM per chronological year of therapy.
    • The low-dose regimen achieved significant growth without excessive bone age advancement.

    Conclusions:

    • An intermittent, lower-dose hGH regimen is effective for treating growth failure in children with hypopituitarism.
    • This approach offers a substantial cost reduction compared to higher-dose therapies.
    • The treatment strategy balances growth promotion with controlled bone maturation.

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