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Related Experiment Video

Updated: May 27, 2026

Developing a Rat Model for Bipolar Disorder

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Published on: May 2, 2025

Tricyclic anti-depressant induced mania.

B B Sethi¹, R Prakash, M Sharma

¹Professor & Head, Department of Psychiatry, K. G.'s Medical College, Lucknow.

Indian Journal of Psychiatry

|November 8, 2011

Summary

Tricyclic antidepressants can induce manic episodes in patients with Monopolar Depression, even at moderate doses. These treatment-emergent manic symptoms were effectively managed with antipsychotic medications.

Related Experiment Videos

Last Updated: May 27, 2026

Developing a Rat Model for Bipolar Disorder

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Published on: May 2, 2025

Area of Science:

Psychiatry
Pharmacology
Neuroscience

Background:

Monopolar Depression is a common mood disorder.
Tricyclic antidepressants (TCAs) are widely used for depression treatment.
Antidepressant-induced mania is a known but infrequent complication.

Purpose of the Study:

To report cases of new-onset mania in Monopolar Depression patients during TCA therapy.
To investigate the characteristics and management of TCA-induced mania.
To discuss potential underlying mechanisms of this adverse effect.

Main Methods:

Case series reporting four patients with Monopolar Depression.
Patients developed manic features during TCA treatment.
Analysis of clinical presentation, dosage, and response to treatment.

Main Results:

Four patients on TCAs developed new-onset manic features.
Manic symptoms emerged late in therapy at moderate TCA doses (125-150 mg/day).
Antipsychotic medication effectively controlled the manic symptoms.

Conclusions:

TCAs can precipitate manic episodes in susceptible individuals with Monopolar Depression.
Late-onset mania during TCA therapy is a recognized phenomenon.
Antipsychotic agents are effective in managing TCA-induced mania.