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Updated: May 27, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives

Facile Preparation of 4-Substituted Quinazoline Derivatives

Published on: February 15, 2016

7-Amino-4-hy-droxy-4-trifluoro-methyl-3,4-dihydro-quinolin-2(1H)-one.

Yuan Qin¹, Haitao Xi, Liang Chen

¹Key Laboratory of Fine Chemical Engineering, Changzhou University, Changzhou 213164, Jiangsu, People's Republic of China.

Acta Crystallographica. Section E, Structure Reports Online

|November 8, 2011

Summary

Researchers synthesized a novel trifluorinated compound using m-phenyl-enediamine and ethyl 4,4,4-trifluoroacetoacetate. Crystal analysis revealed specific intermolecular interactions influencing its packing structure.

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Area of Science:

Organic Chemistry
Crystallography

Background:

Synthesis of novel fluorinated organic compounds is crucial for materials science.
Understanding intermolecular forces is key to predicting crystal structures and properties.

Purpose of the Study:

To synthesize and characterize a new trifluorinated compound.
To investigate the intermolecular interactions governing its crystal packing.

Main Methods:

Chemical synthesis involving condensation reaction.
Single-crystal X-ray diffraction analysis.

Main Results:

Successful synthesis of the target compound C(10)H(9)F(3)N(2)O(2).
Identification of significant intermolecular interactions: C-H⋯F, N-H⋯F, O-H⋯N, and N-H⋯O.

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Last Updated: May 27, 2026

Facile Preparation of 4-Substituted Quinazoline Derivatives

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Published on: February 15, 2016

Optimized Griess Reaction for UV-Vis and Naked-eye Determination of Anti-malarial Primaquine

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Detailed analysis of crystal packing influenced by these interactions.

Conclusions:

The synthesized compound exhibits a crystal structure stabilized by a network of hydrogen and halogen bonds.
The study provides insights into structure-property relationships for fluorinated organic molecules.