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Updated: May 27, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Dibromido(2,3-di-2-pyridyl-pyrazine-κN,N)platinum(II)
1School of Applied Chemical Engineering, The Research Institute of Catalysis, Chonnam National University, Gwangju 500-757, Republic of Korea.
Abstract:
The Pt(II) ion in the title complex, [PtBr(2)(C(14)H(10)N(4))], is four-coordinated in a distorted square-planar environment by two N atoms of a chelating 2,3-di-2-pyridyl-pyrazine ligand and two bromide anions. In the crystal, the pyridyl ring coordinated to the Pt atom is inclined slightly to its carrier pyrazine ring [dihedral angle = 14.7 (2)°], whereas the uncoordinated pyridyl ring is inclined considerably to the pyrazine ring [dihedral angle = 51.9 (3)°]. The dihedral angle between the two pyridyl rings is 57.7 (3)°. Two complex mol-ecules are assembled through inter-molecular C-H⋯N hydrogen bonds, forming a dimer-type species. Intra-molecular C-H⋯Br and C-H⋯N hydrogen bonds are also present.
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