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Updated: May 27, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Dibromido(2,3-di-2-pyridyl-pyrazine-κN,N)platinum(II)
1School of Applied Chemical Engineering, The Research Institute of Catalysis, Chonnam National University, Gwangju 500-757, Republic of Korea.
Abstract:
The Pt(II) ion in the title complex, [PtBr(2)(C(14)H(10)N(4))], has a slightly distorted square-planar environment defined by the two pyridyl N atoms of the chelating 2,3-di-2-pyridyl-pyrazine ligand and two bromide anions. In the crystal, the pyridyl rings are considerably inclined to the least-squares plane of the PtBr(2)N(2) unit [maximum deviation = 0.064 (2) Å] with dihedral angles of 65.2 (2) and 66.0 (2)°. The nearly planar pyrazine ring [maximum deviation = 0.020 (5) Å] is almost perpendicular to the unit plane with a dihedral angle of 89.2 (2)°. Two independent weak inter-molecular C-H⋯Br hydrogen bonds, both involving the same Br atom as a hydrogen-bond acceptor, give rise to chains running along the a and b axes, forming a layer structure extending parallel to (001). The complexes are stacked in columns along the a axis. When viewed down the b axis, the successive complexes stack in the opposite direction.
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