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Related Concept Videos

Five-Membered Heterocyclic Aromatic Compounds: Overview01:13

Five-Membered Heterocyclic Aromatic Compounds: Overview

Heterocyclic aromatic compounds are cyclic compounds that are aromatic and have one or more heteroatoms—atoms other than carbon, in the ring. Depending upon the number of atoms present in the ring, they can be either five or six-membered. Examples of five-membered heterocyclic aromatic compounds include pyrrole, furan, thiophene, and imidazole. Pyrrole consists of one nitrogen atom having one lone pair of electrons. Furan and thiophene have one oxygen and one sulfur heteroatom, respectively.
Basicity of Heterocyclic Aromatic Amines01:25

Basicity of Heterocyclic Aromatic Amines

Heterocyclic amines, where the N atom is a part of an alicyclic system, are similar in basicity to alkylamines. Interestingly, the heterocyclic amine having a nitrogen atom as part of an aromatic ring has much less basicity than its corresponding alicyclic counterpart. For this reason, as presented in Figure 1, piperidine (pKb = 2.8) is significantly more basic than pyridine (pKb = 8.8).
Biosynthesis of Nucleic Acids01:28

Biosynthesis of Nucleic Acids

Nucleic acid biosynthesis is a fundamental biochemical process that produces the purine and pyrimidine nucleotides essential for DNA and RNA synthesis. This pathway maintains a balanced nucleotide pool, preventing imbalances that could jeopardize genetic integrity and cellular function. Given the crucial role of nucleotides, their synthesis is tightly regulated to ensure proper cellular homeostasis.Purine BiosynthesisThe biosynthesis of purine nucleotides begins with ribose-5-phosphate, a...
Phase II Reactions: Methylation Reactions01:17

Phase II Reactions: Methylation Reactions

Methylation is a phase II biotransformation process involving the attachment of a methyl group to a substrate. Enzymes known as methyltransferases orchestrate this reaction.
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...

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Related Experiment Video

Updated: May 27, 2026

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
05:07

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines

Published on: June 23, 2019

5-Methyl-2-pyridone.

Shulin Mao1, Luo Yanghui, Pan Meiling

  • 1Ordered Matter Science Research Center, College of Chemistry and Chemical Engineering, Southeast University, Nanjing 210096, People's Republic of China.

Acta Crystallographica. Section E, Structure Reports Online
|November 8, 2011
PubMed
Summary
This summary is machine-generated.

The crystal structure of C(6)H(7)NO features intermolecular N-H⋯O hydrogen bonds, forming inversion dimers. Additional weak C-H⋯O bonds further stabilize this molecular arrangement.

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Area of Science:

  • Crystallography
  • Solid-state chemistry
  • Molecular structure

Background:

  • Understanding intermolecular forces is crucial for predicting material properties.
  • Hydrogen bonding plays a significant role in molecular self-assembly and crystal engineering.

Purpose of the Study:

  • To elucidate the crystal structure of C(6)H(7)NO.
  • To identify and characterize the intermolecular interactions stabilizing the crystal lattice.

Main Methods:

  • Single-crystal X-ray diffraction was employed to determine the atomic arrangement.
  • Analysis of hydrogen bond geometries (N-H⋯O and C-H⋯O) was performed.

Main Results:

  • The crystal structure is characterized by the formation of inversion dimers mediated by intermolecular N-H⋯O hydrogen bonds.
  • Weak C-H⋯O hydrogen bonds were also identified, contributing to the overall structural stability.

Conclusions:

  • The crystal packing of C(6)H(7)NO is primarily governed by strong intermolecular N-H⋯O hydrogen bonds.
  • The interplay of different hydrogen bonding types dictates the final three-dimensional structure and stability.