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Updated: May 27, 2026
09:11
Alternating Magnetic Field-Responsive Hybrid Gelatin Microgels for Controlled Drug Release
Published on: February 13, 2016
Phase-shift, stimuli-responsive drug carriers for targeted delivery
Brian E O'Neill1, Natalya Rapoport
1Department of Translational Imaging, The Methodist Hospital Research Institute, MC R6-414, 6670 Bertner Street, Houston, TX 77030, USA.
Therapeutic Delivery
|November 8, 2011
Summary
Phase-shift nanoparticles and microparticles utilize external energy to change state, enabling targeted drug delivery. This technology offers novel ways to disrupt environments and release medications effectively.
Area of Science:
- Biotechnology
- Nanotechnology
- Medical Devices
Background:
- Directed energy technologies are increasingly applied in medicine.
- Directed drug delivery is a key area for technological advancement.
- Phase-shift particles offer unique mechanisms for drug delivery applications.
Purpose of the Study:
- To review phase-shift nanoparticles and microparticles for drug delivery.
- To detail ultrasound and laser-activated phase-shift particles.
- To discuss phase-shift based drug delivery mechanisms and compare them with competing technologies.
Main Methods:
- Review of scientific literature on phase-shift nanoparticles and microparticles.
- Detailed analysis of ultrasound and laser activation mechanisms.
- Comparison of phase-shift drug delivery with existing methods.
Main Results:
- Phase-shift particles, triggered by external energy, can transition from liquid to gas.
- These particles can disrupt local environments to enhance drug transport and release.
- Ultrasound and laser activation are key methods for triggering these particles.
Conclusions:
- Phase-shift nanoparticles and microparticles show significant promise for directed drug delivery.
- External energy-triggered phase transitions offer novel therapeutic possibilities.
- Further research into these technologies could revolutionize drug delivery systems.
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