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Related Experiment Video

Updated: May 27, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Funisitis and chorionic vasculitis: relation to chorioamnionitis, timing and scoring.

Geoffrey Machin¹

¹geoffmachin@shaw.ca

Fetal and Pediatric Pathology

|November 9, 2011

Summary

This summary is machine-generated.

A new staging system for umbilical cord inflammation (funisitis) was developed. Advanced funisitis stages correlate with severe chorioamnionitis, indicating a prolonged inflammatory process.

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Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

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Last Updated: May 27, 2026

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development

Published on: June 24, 2020

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

Published on: October 10, 2025

Area of Science:

Perinatal pathology
Obstetrics
Neonatal inflammation

Background:

Histologic chorioamnionitis and umbilical cord inflammation (funisitis) are common findings in adverse pregnancy outcomes.
Understanding the progression and timing of funisitis is crucial for clinical management.

Purpose of the Study:

To develop a staging system for funisitis based on histologic findings.
To correlate the stage of funisitis with the stage of chorioamnionitis.
To estimate the time interval between the onset of chorioamnionitis and different stages of funisitis.

Main Methods:

Analysis of 500 consecutive cases with histologic chorioamnionitis and umbilical cord inflammation.
Development of a staging system for funisitis.
Correlation analysis between funisitis stage and chorioamnionitis stage.

Main Results:

A progressive staging system for funisitis was established, detailing venous and arterial involvement.
Venous involvement precedes arterial involvement in funisitis progression.
Advanced funisitis stages (arterial and full involvement) show a strong association with severe chorioamnionitis (Stage III/IV).

Conclusions:

The developed staging system provides a framework for evaluating funisitis severity.
The correlation suggests that advanced funisitis implies a significant time lapse after initial amniotic cavity inflammation.
This correlation aids in estimating the timing of inflammatory events during pregnancy.