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Cancer02:18

Cancer

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Epigenetic Regulation01:46

Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Epigenetic Regulation01:37

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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What is Cancer?02:12

What is Cancer?

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Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
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Skin Cancer01:30

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Related Experiment Video

Updated: Jan 31, 2026

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres
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Epigenetic changes in colorectal cancer.

Yan Jia1, Mingzhou Guo

  • 1Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing, People's Republic of China.

Chinese Journal of Cancer
|November 9, 2011
PubMed
Summary

Epigenetic alterations like DNA methylation and histone modifications are key in colorectal cancer development. Understanding these changes, including microRNA patterns, is crucial for potential therapeutic strategies.

Area of Science:

  • Oncology
  • Epigenetics
  • Molecular Biology

Background:

  • Epigenetic alterations are common in human colorectal cancer.
  • Key changes include global hypomethylation, promoter hypermethylation, histone modifications, and altered microRNA profiles.
  • Loss of imprinting (LOI) is linked to colorectal neoplasia, and folate deficiency may contribute to carcinogenesis via epigenetic changes.

Purpose of the Study:

  • To review the major epigenetic changes in colorectal cancer.
  • Focus on DNA methylation, histone modification, and microRNA alterations.
  • Highlight the role of non-coding RNA as an epigenetic marker.

Main Methods:

  • Literature review of epigenetic mechanisms in colorectal cancer.
  • Analysis of studies on DNA methylation, histone modification, and microRNA.

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  • Examination of the role of folate deficiency and potential therapeutic agents.

    • Main Results:

    • Colorectal cancer exhibits significant epigenetic dysregulation, including DNA hypomethylation and hypermethylation.
    • Histone modifications and altered microRNA expression are prominent features.
    • Non-coding RNAs represent emerging epigenetic markers.

    Conclusions:

    • Epigenetic modifications are fundamental to colorectal cancer pathogenesis.
    • Targeting these epigenetic changes, such as with HDAC inhibitors or demethylating agents, holds therapeutic potential.
    • Further research into microRNA and non-coding RNA roles is warranted.