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Related Experiment Videos

Stroke risk and NSAIDs: an Australian population-based study.

Gillian E Caughey¹, Elizabeth E Roughead, Nicole Pratt

¹Quality Use of Medicines and Pharmacy Research Centre, Sansom Institute, University of South Australia, Adelaide, SA. gillian.caughey@unisa.edu.au

The Medical Journal of Australia

|November 9, 2011

Summary

Starting non-steroidal anti-inflammatory drugs (NSAIDs) increases stroke risk. This study found a nearly twofold higher risk of hospitalization for stroke in new NSAID users, highlighting the need for careful patient assessment.

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Area of Science:

Cardiovascular epidemiology
Pharmacovigilance
Drug safety

Background:

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for pain and inflammation.
Concerns exist regarding the cardiovascular safety of NSAIDs.
Understanding the specific risk of stroke associated with NSAID initiation is crucial.

Purpose of the Study:

To investigate the association between initiating non-steroidal anti-inflammatory drug (NSAID) use and the risk of stroke.
To quantify the increased risk of stroke hospitalization linked to new NSAID prescriptions.

Main Methods:

A retrospective cohort study involving 162,065 Australian veterans.
Data collected from January 1, 2001, to December 31, 2008.
Prescription event sequence symmetry analysis was employed to assess the temporal relationship between NSAID dispensing and stroke events.

Main Results:

The absolute risk of stroke was low (7.1/1000 people/year).
Incident NSAID use was associated with a 1.88-fold increased risk of stroke hospitalization (95% CI, 1.70-2.08).
This translates to an additional 13.4 strokes per 1000 people per year, with varying risks across different NSAIDs.

Conclusions:

Initiating NSAID therapy is linked to an elevated risk of stroke.
Healthcare providers should exercise caution, assess individual cardiovascular risk, and weigh benefits against risks when prescribing NSAIDs.
Increased awareness of potential serious adverse cardiovascular events is necessary for safe NSAID use.