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Related Concept Videos

Clamper Circuit01:14

Clamper Circuit

A clamper circuit, also known as a DC restorer, represents a specialized variant of the rectifier circuit, notable for its method of taking the output across the diode rather than the capacitor. This configuration lends to several distinctive applications, particularly in handling square wave inputs.
Within this circuit, the diode's orientation prompts the capacitor to charge up to the level of the most negative peak of the input signal. Upon reaching this state, the diode ceases to conduct,...
Clipper Circuit01:18

Clipper Circuit

A clipper circuit is a fundamental wave-shaping device that harnesses the unique properties of diodes to alter and control waveform characteristics. This technology is widely used in electronic devices, especially in television and radar communication systems, where it enhances waveform modulation in both transmitters and receivers.
The operation of a clipper circuit can be exemplified by analyzing a dual-clipper configuration setup that integrates two ideal diodes, each paired with a biasing...
Precipitate Formation and Particle Size Control01:16

Precipitate Formation and Particle Size Control

In precipitation gravimetry, the precipitating agent should react specifically or selectively with the analyte. While a specific reagent reacts with the analyte alone, a selective reagent can react with a limited number of chemical species.
The obtained precipitate should be either a pure substance of known composition or easily converted to one by a simple process, such as ignition or drying. In addition, the precipitate should be insoluble and easily filterable. In general, filterability...
Capacitor With A Dielectric01:18

Capacitor With A Dielectric

Parallel plate capacitors consist of two conducting plates separated by a certain distance. However, it is mechanically difficult to hold the large plates parallel to each other without actual contact. Hence, a dielectric layer is commonly placed between the plates, which provides an easy solution for holding the plates together with a small gap and increases the capacitance of the capacitor.
Dielectrics are non-conducting materials with no free or loosely bound electrons. When a dielectric is...
Integration of Synaptic Events01:28

Integration of Synaptic Events

Synaptic integration mainly includes the summation of graded potentials. Graded potentials, regardless of their type, cause subtle alterations in membrane voltage, resulting in either depolarization or hyperpolarization. These incremental changes, when combined or summed, can propel the neuron toward its threshold. Consider, for example, a membrane experiencing a +15 mV shift, causing it to depolarize from -70 mV to -55 mV. In this scenario, graded potentials govern the membrane's ability to...
Vesicular Tubular Clusters01:45

Vesicular Tubular Clusters

After budding out from the ER membrane, some COPII vesicles lose their coat and fuse with one another to form larger vesicles and interconnected tubules called vesicular tubular clusters or VTCs. These clusters constitute a compartment at the ER-Golgi interface known as ERGIC (Endoplasmic Reticulum Golgi Intermediate Compartment). The ERGIC is a mobile membrane-bound cargo transport system that sorts proteins secreted from ER and delivers them to the Golgi.
With the help of motor proteins such...

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Related Experiment Video

Updated: May 27, 2026

High Throughput Single-cell and Multiple-cell Micro-encapsulation
16:19

High Throughput Single-cell and Multiple-cell Micro-encapsulation

Published on: June 15, 2012

Efficient encapsulation with plug-triggered drop formation.

Adam R Abate1, Assaf Rotem, Julian Thiele

  • 1Department of Physics, School of Engineering and Applied Sciences, Harvard University, Cambridge, Massachusetts 02138, USA. adam.abate@ucsf.edu

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
|November 9, 2011
PubMed
Summary
This summary is machine-generated.

Microfluidic devices create uniform micro-drops for encapsulating cells and particles. A new method uses object inflow to plug the nozzle, ensuring efficient, single-object encapsulation per drop.

More Related Videos

Title Cell Encapsulation by Droplets
13:10

Title Cell Encapsulation by Droplets

Published on: October 1, 2007

Bilayer Microfluidic Device for Combinatorial Plug Production
07:03

Bilayer Microfluidic Device for Combinatorial Plug Production

Published on: December 1, 2023

Related Experiment Videos

Last Updated: May 27, 2026

High Throughput Single-cell and Multiple-cell Micro-encapsulation
16:19

High Throughput Single-cell and Multiple-cell Micro-encapsulation

Published on: June 15, 2012

Title Cell Encapsulation by Droplets
13:10

Title Cell Encapsulation by Droplets

Published on: October 1, 2007

Bilayer Microfluidic Device for Combinatorial Plug Production
07:03

Bilayer Microfluidic Device for Combinatorial Plug Production

Published on: December 1, 2023

Area of Science:

  • Biotechnology
  • Materials Science
  • Chemical Engineering

Background:

  • Microfluidic devices are crucial for generating monodisperse microscale drops.
  • These drops are vital for encapsulating cells, microgel particles, and other drops.
  • Current methods often suffer from inefficient object encapsulation, leading to unusable drops.

Purpose of the Study:

  • To describe a novel phenomenon for highly efficient object encapsulation in microfluidic drops.
  • To address the challenge of inefficient encapsulation in current microdrop generation techniques.

Main Methods:

  • Utilizing microfluidic devices for drop formation.
  • Employing a technique where the object's inflow plugs the drop maker nozzle.
  • Controlling outer phase injection to pinch off the drop and encapsulate the object.

Main Results:

  • Achieved highly efficient encapsulation of objects within microfluidic drops.
  • Demonstrated a method yielding precisely one object encapsulated per drop.
  • Overcame the issue of improperly filled or unusable drops.

Conclusions:

  • The described phenomenon significantly improves encapsulation efficiency in microfluidic drop generation.
  • This technique offers a reliable method for synthesizing monodisperse particles and capsules with single-object encapsulation.
  • The findings have broad implications for high-throughput biology and particle synthesis applications.