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The force applied by fluids against a surface, known as hydrostatic pressure, initiates the transfer of fluid among different compartments. Within our blood vessels, the blood's hydrostatic pressure is a result of the heart's pumping action. At the arteriolar end of capillaries, hydrostatic pressure (capillary blood pressure) exceeds the opposing colloid osmotic pressure created primarily by plasma proteins like albumin. This discrepancy in pressure propels plasma and nutrients from the...
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Transcellular transport of solutes is the movement of substances like monosaccharides and amino acids through polarized cells. This transport mechanism is primarily seen in epithelial and endothelial cells aided by membrane transport proteins such as channels and transporters. The tight junctions between these cells confine the membrane proteins to the two sides of the cell. The epithelial cells have distinct apical and basolateral domains. In contrast, the endothelial cells show the luminal...
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Related Experiment Video

Updated: May 27, 2026

Demonstration of Membrane Transport of Histidine using Goat Intestinal Inverted Sacs: An Experiential Pedagogical Tool for Undergraduates
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Fluid transport by active elastic membranes.

Arthur A Evans1, Eric Lauga

  • 1Department of Physics, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA.

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics
|November 9, 2011
PubMed
Summary

Flexible membranes can self-propel or transport fluids when internally forced, not just when their shape is prescribed. This study models active stresses to predict membrane shape and fluid motion.

Area of Science:

  • Fluid dynamics
  • Soft matter physics
  • Biophysics

Background:

  • Flexible membranes in viscous fluids can self-propel or induce fluid transport when deforming.
  • Previous research prescribed membrane deformation kinematics.
  • This study explores internally forced membrane dynamics where deformation is not predetermined.

Purpose of the Study:

  • To investigate fluid transport and self-propulsion of flexible membranes driven by internal active stresses.
  • To develop theoretical models for internally forced membrane dynamics.
  • To analyze the resulting membrane shape and fluid motion.

Main Methods:

  • Developing two models for active internal forcing: prescribed bending moments and active normal stresses from fluid pumping.
  • Asymptotic calculations for small forcing amplitudes to determine membrane shape and fluid velocities.

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  • Utilizing scaling analysis to validate theoretical results.
  • Main Results:

    • Derived analytical solutions for membrane shape and fluid transport velocities under active internal forcing.
    • Demonstrated that internal forcing, rather than prescribed kinematics, dictates membrane deformation and fluid motion.
    • Showcased the predictive power of the developed models for active membrane systems.

    Conclusions:

    • Internally forced flexible membranes offer a novel mechanism for controlled self-propulsion and fluid transport.
    • The models provide a framework for understanding and designing active membrane systems.
    • This work advances the understanding of active matter and microfluidic transport.