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Related Experiment Video

Updated: May 27, 2026

Process Optimization using High Throughput Automated Micro-Bioreactors in Chinese Hamster Ovary Cell Cultivation

Process Optimization using High Throughput Automated Micro-Bioreactors in Chinese Hamster Ovary Cell Cultivation

Published on: May 18, 2020

Recent advances in process assessment and optimisation.

A Van Loey¹, M Hendrickx, C Smout

¹Katholieke Universiteit Leuven Department of Food and Microbial Technology Laboratory of Food Technology, Kardinaal Mercierlaan 92, B3001, Heverlee, Belgium.

|November 9, 2011

Summary

This study reviews methods for quantifying the impact of time and temperature on food preservation. It covers physical-mathematical approaches and time-temperature integrators, highlighting recent advancements and optimization trends.

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Area of Science:

Food Science
Process Engineering

Background:

Food preservation is crucial for safety and shelf-life.
Thermal processing is a common preservation method.
Accurate evaluation of time-temperature impact is essential.

Purpose of the Study:

To review quantitative methods for assessing integrated time-temperature effects in thermal food preservation.
To discuss physical-mathematical approaches and time-temperature integrators.
To highlight recent advancements and future trends in thermal process optimization.

Main Methods:

Literature review of existing methods.
Analysis of physical-mathematical modeling.
Evaluation of time-temperature integrator technologies.

Main Results:

Current methods allow quantitative assessment of time-temperature impact.
Both physical-mathematical and integrator approaches have limitations and strengths.
Recent evolutions show promise for more accurate monitoring.

Conclusions:

Accurate monitoring of time-temperature history is vital for effective food preservation.
Advancements in evaluation methods and process optimization are ongoing.
Future research should focus on integrating these technologies for enhanced food safety and quality.