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Published on: October 24, 2018
Antidepressive and anxiolytic activity of selective estrogen receptor modulators in ovariectomized mice submitted to
Isabel Calmarza-Font1, Natalia Lagunas, Luis M Garcia-Segura
1Instituto Cajal, CSIC, E-28002 Madrid, Spain.
Abstract:
Estradiol has antidepressive and anxiolytic actions. However, its therapeutic use is limited by its peripheral effects. Selective estrogen receptor modulators may represent an alternative to estradiol for the treatment of depressive symptoms. Here we report that tamoxifen and raloxifene decrease immobility time in the forced swim test and increases the time spent in open arms in the elevated plus maze in ovariectomized mice submitted to chronic unpredictable stress.
Insights
Selective estrogen receptor modulators, like tamoxifen and raloxifene, show promise for treating depression by reducing immobility and anxiety behaviors in stressed mice.
Area of Science:
- Neuroendocrinology
- Pharmacology
- Behavioral Neuroscience
Background:
- Estradiol exhibits antidepressant and anxiolytic properties.
- Therapeutic application of estradiol is constrained by peripheral side effects.
- Selective estrogen receptor modulators (SERMs) offer a potential alternative for managing depressive symptoms.
Purpose of the Study:
- To investigate the efficacy of SERMs, specifically tamoxifen and raloxifene, as potential antidepressants.
- To evaluate the anxiolytic and antidepressant-like effects of tamoxifen and raloxifene in a preclinical model of depression.
Main Methods:
- Ovariectomized mice were subjected to chronic unpredictable stress to induce depressive-like behaviors.
- The forced swim test was employed to assess immobility time as a measure of depression.
- The elevated plus maze was used to evaluate anxiety levels by measuring time spent in open arms.
Main Results:
- Tamoxifen and raloxifene significantly decreased immobility time in the forced swim test.
- Both tamoxifen and raloxifene increased the time spent in the open arms of the elevated plus maze.
- These findings suggest antidepressant and anxiolytic effects of the tested SERMs.
Conclusions:
- Tamoxifen and raloxifene demonstrate potential as therapeutic agents for depressive symptoms.
- SERMs may offer a viable alternative to estradiol for treating depression, mitigating peripheral side effects.
- Further research into SERMs for mood disorders is warranted based on these preclinical findings.
